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Mechanisms of Cellular Uptake of Cell-Penetrating Peptides
Joint Authors
Langel, Ülo
Lindberg, Staffan
Gräslund, Astrid
Madani, Fatemeh
Futaki, Shiroh
Source
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-04-07
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Recently, much attention has been given to the problem of drug delivery through the cell-membrane in order to treat and manage several diseases.
The discovery of cell penetrating peptides (CPPs) represents a major breakthrough for the transport of large-cargo molecules that may be useful in clinical applications.
CPPs are rich in basic amino acids such as arginine and lysine and are able to translocate over membranes and gain access to the cell interior.
They can deliver large-cargo molecules, such as oligonucleotides, into cells.
Endocytosis and direct penetration have been suggested as the two major uptake mechanisms, a subject still under debate.
Unresolved questions include the detailed molecular uptake mechanism(s), reasons for cell toxicity, and the delivery efficiency of CPPs for different cargoes.
Here, we give a review focused on uptake mechanisms used by CPPs for membrane translocation and certain experimental factors that affect the mechanism(s).
American Psychological Association (APA)
Madani, Fatemeh& Lindberg, Staffan& Langel, Ülo& Futaki, Shiroh& Gräslund, Astrid. 2011. Mechanisms of Cellular Uptake of Cell-Penetrating Peptides. Journal of Biophysics،Vol. 2011, no. 2011, pp.1-10.
https://search.emarefa.net/detail/BIM-470282
Modern Language Association (MLA)
Madani, Fatemeh…[et al.]. Mechanisms of Cellular Uptake of Cell-Penetrating Peptides. Journal of Biophysics No. 2011 (2011), pp.1-10.
https://search.emarefa.net/detail/BIM-470282
American Medical Association (AMA)
Madani, Fatemeh& Lindberg, Staffan& Langel, Ülo& Futaki, Shiroh& Gräslund, Astrid. Mechanisms of Cellular Uptake of Cell-Penetrating Peptides. Journal of Biophysics. 2011. Vol. 2011, no. 2011, pp.1-10.
https://search.emarefa.net/detail/BIM-470282
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-470282