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Lack of Association of Childhood Partial Epilepsy with Brain Derived Neurotrophic Factor Gene
Joint Authors
Bora, Elcin
Giray Bozkaya, Ozlem
Ulgenalp, Ayfer
Ozturk, Aysel
Unalp, Aycan
Ercal, Derya
Cankaya, Tufan
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-05-01
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Natural & Life Sciences (Multidisciplinary)
Medicine
Information Technology and Computer Science
Abstract EN
Brain-derived factor (BDNF) is a member of neurotrophin family and is localized and upregulated in areas implicated in epileptogenesis.
Several lines of evidence make the BDNF gene a plausible candidate gene for predisposition to epilepsy.
In this study, we tested that BDNF might be involved in the etiology of childhood PE.
To assess whether BDNF gene C270T polimorphism could be implicated in vulnerability to PE, we conducted a case-control association analysis (112 partial epileptic and 100 controls) in Turkish children.
Epileptic children were divided into two groups: 1—idiopathic (n=85) and 2—symptomathic epilepsy (n=27).
There was no significant difference in genotypic distribution and allelic frequencies of the BDNF gene C270T polimorphism between the PE and control groups.
However, the BDNF gene TT genotype was more frequently seen in the epileptic children (15 versus 11 patients, resp.).
Interestingly, in the epilepsy group, both two children with TT genotype have posttraumatic epilepsy.
The data indicate a possible association with the 270T genotype of the BDNF gene with a posttraumatic epilepsy.
To draw any conclusion, further studies using larger sample sizes should be carried out in various ethnic populations in childhood epilepsies.
American Psychological Association (APA)
Unalp, Aycan& Bora, Elcin& Cankaya, Tufan& Giray Bozkaya, Ozlem& Ercal, Derya& Ozturk, Aysel…[et al.]. 2012. Lack of Association of Childhood Partial Epilepsy with Brain Derived Neurotrophic Factor Gene. The Scientific World Journal،Vol. 2012, no. 2012, pp.1-5.
https://search.emarefa.net/detail/BIM-470287
Modern Language Association (MLA)
Unalp, Aycan…[et al.]. Lack of Association of Childhood Partial Epilepsy with Brain Derived Neurotrophic Factor Gene. The Scientific World Journal No. 2012 (2012), pp.1-5.
https://search.emarefa.net/detail/BIM-470287
American Medical Association (AMA)
Unalp, Aycan& Bora, Elcin& Cankaya, Tufan& Giray Bozkaya, Ozlem& Ercal, Derya& Ozturk, Aysel…[et al.]. Lack of Association of Childhood Partial Epilepsy with Brain Derived Neurotrophic Factor Gene. The Scientific World Journal. 2012. Vol. 2012, no. 2012, pp.1-5.
https://search.emarefa.net/detail/BIM-470287
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-470287