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Whole Body Microwave Irradiation for Improved Dacarbazine Therapeutical Action in Cutaneous Melanoma Mouse Model
Joint Authors
Albulescu, Lucian
Constantin, Carolina
Martin, Diana
Iacob, Nicusor
Ighigeanu, Daniel
Neagu, Monica
Source
Radiology Research and Practice
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-11-26
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
A cutaneous melanoma mouse model was used to test the efficacy of a new therapeutical approach that uses low doses of cytostatics in conjunction with mild whole body microwave exposure of 2.45 GHz in order to enhance cytostatics antitumoral effect.
Materials and Methods.
A microwave exposure system for C57BL/6 mouse whole body microwave irradiation was designed; groups of 40 mice (males and females) bearing experimental tumours were subjected to a combined therapy comprising low doses of dacarbazine in combination with mild whole body irradiation.
Clinical parameters and serum cytokine testing using xMAP technology were performed.
Results.
The group that was subjected to combined therapy, microwave and cytostatic, had the best clinical evolution in terms of overall survival, tumour volume, and metastatic potential.
At day 14 the untreated group had 100% mortality, while in the combined therapy group 40% of mice were surviving.
Quantifying serum IL-1β, IL-6, IL-10, IL-12 (p70), IFN-γ, GM-CSF, TNF-α, MIP-1α, MCP-1, and KC during tumorigenesis and therapy found that the combined experimental therapy decreases all the inflammatory cytokines, except chemokine MCP-1 that was found increased, suggesting an increase of the anti-tumoral immune response triggered by the combined therapy.
The overall metastatic process is decreased in the combined therapy group.
American Psychological Association (APA)
Neagu, Monica& Constantin, Carolina& Martin, Diana& Albulescu, Lucian& Iacob, Nicusor& Ighigeanu, Daniel. 2013. Whole Body Microwave Irradiation for Improved Dacarbazine Therapeutical Action in Cutaneous Melanoma Mouse Model. Radiology Research and Practice،Vol. 2013, no. 2013, pp.1-10.
https://search.emarefa.net/detail/BIM-470290
Modern Language Association (MLA)
Neagu, Monica…[et al.]. Whole Body Microwave Irradiation for Improved Dacarbazine Therapeutical Action in Cutaneous Melanoma Mouse Model. Radiology Research and Practice No. 2013 (2013), pp.1-10.
https://search.emarefa.net/detail/BIM-470290
American Medical Association (AMA)
Neagu, Monica& Constantin, Carolina& Martin, Diana& Albulescu, Lucian& Iacob, Nicusor& Ighigeanu, Daniel. Whole Body Microwave Irradiation for Improved Dacarbazine Therapeutical Action in Cutaneous Melanoma Mouse Model. Radiology Research and Practice. 2013. Vol. 2013, no. 2013, pp.1-10.
https://search.emarefa.net/detail/BIM-470290
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-470290