Functional Mechanisms and Roles of Adaptor Proteins in Abl-Regulated Cytoskeletal Actin Dynamics
Joint Authors
Sato, Mizuho
Takeya, Tatsuo
Maruoka, Masahiro
Source
Journal of Signal Transduction
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-05-17
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
Abl is a nonreceptor tyrosine kinase and plays an essential role in the modeling and remodeling of F-actin by transducing extracellular signals.
Abl and its paralog, Arg, are unique among the tyrosine kinase family in that they contain an unusual extended C-terminal half consisting of multiple functional domains.
This structural characteristic may underlie the role of Abl as a mediator of upstream signals to downstream signaling machineries involved in actin dynamics.
Indeed, a group of SH3-containing accessory proteins, or adaptor proteins, have been identified that bind to a proline-rich domain of the C-terminal portion of Abl and modulate its kinase activity, substrate recognition, and intracellular localization.
Moreover, the existence of signaling cascade and biological outcomes unique to each adaptor protein has been demonstrated.
In this paper, we summarize functional roles and mechanisms of adaptor proteins in Abl-regulated actin dynamics, mainly focusing on a family of adaptor proteins, Abi.
The mechanism of Abl's activation and downstream signaling mediated by Abi is described in comparison with those by another adaptor protein, Crk.
American Psychological Association (APA)
Sato, Mizuho& Maruoka, Masahiro& Takeya, Tatsuo. 2012. Functional Mechanisms and Roles of Adaptor Proteins in Abl-Regulated Cytoskeletal Actin Dynamics. Journal of Signal Transduction،Vol. 2012, no. 2012, pp.1-13.
https://search.emarefa.net/detail/BIM-470301
Modern Language Association (MLA)
Sato, Mizuho…[et al.]. Functional Mechanisms and Roles of Adaptor Proteins in Abl-Regulated Cytoskeletal Actin Dynamics. Journal of Signal Transduction No. 2012 (2012), pp.1-13.
https://search.emarefa.net/detail/BIM-470301
American Medical Association (AMA)
Sato, Mizuho& Maruoka, Masahiro& Takeya, Tatsuo. Functional Mechanisms and Roles of Adaptor Proteins in Abl-Regulated Cytoskeletal Actin Dynamics. Journal of Signal Transduction. 2012. Vol. 2012, no. 2012, pp.1-13.
https://search.emarefa.net/detail/BIM-470301
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-470301