Genetic Diversity of Toll-Like Receptors and Immunity to M. leprae Infection
Joint Authors
Tapping, Richard I.
Hart, Bryan E.
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-03-18
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
Genetic association studies of leprosy cohorts across the world have identified numerous polymorphisms which alter susceptibility and outcome to infection with Mycobacterium leprae.
As expected, many of the polymorphisms reside within genes that encode components of the innate and adaptive immune system.
Despite the preponderance of these studies, our understanding of the mechanisms that underlie these genetic associations remains sparse.
Toll-like receptors (TLRs) have emerged as an essential family of innate immune pattern recognition receptors which play a pivotal role in host defense against microbes, including pathogenic strains of mycobacteria.
This paper will highlight studies which have uncovered the association of specific TLR gene polymorphisms with leprosy or tuberculosis: two important diseases resulting from mycobacterial infection.
This analysis will focus on the potential influence these polymorphic variants have on TLR expression and function and how altered TLR recognition or signaling may contribute to successful antimycobacterial immunity.
American Psychological Association (APA)
Hart, Bryan E.& Tapping, Richard I.. 2012. Genetic Diversity of Toll-Like Receptors and Immunity to M. leprae Infection. Journal of Tropical Medicine،Vol. 2012, no. 2012, pp.1-12.
https://search.emarefa.net/detail/BIM-470308
Modern Language Association (MLA)
Hart, Bryan E.& Tapping, Richard I.. Genetic Diversity of Toll-Like Receptors and Immunity to M. leprae Infection. Journal of Tropical Medicine No. 2012 (2012), pp.1-12.
https://search.emarefa.net/detail/BIM-470308
American Medical Association (AMA)
Hart, Bryan E.& Tapping, Richard I.. Genetic Diversity of Toll-Like Receptors and Immunity to M. leprae Infection. Journal of Tropical Medicine. 2012. Vol. 2012, no. 2012, pp.1-12.
https://search.emarefa.net/detail/BIM-470308
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-470308