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Sulforaphane as a Potential Protective Phytochemical against Neurodegenerative Diseases
Joint Authors
Hrelia, Patrizia
Malaguti, Marco
Morroni, Fabiana
Angeloni, Cristina
Hrelia, Silvana
Tarozzi, Andrea
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-07-25
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Natural & Life Sciences (Multidisciplinary)
Biology
Abstract EN
A wide variety of acute and chronic neurodegenerative diseases, including ischemic/traumatic brain injury, Alzheimer’s disease, and Parkinson's disease, share common characteristics such as oxidative stress, misfolded proteins, excitotoxicity, inflammation, and neuronal loss.
As no drugs are available to prevent the progression of these neurological disorders, intervention strategies using phytochemicals have been proposed as an alternative form of treatment.
Among phytochemicals, isothiocyanate sulforaphane, derived from the hydrolysis of the glucosinolate glucoraphanin mainly present in Brassica vegetables, has demonstrated neuroprotective effects in several in vitro and in vivo studies.
In particular, evidence suggests that sulforaphane beneficial effects could be mainly ascribed to its peculiar ability to activate the Nrf2/ARE pathway.
Therefore, sulforaphane appears to be a promising compound with neuroprotective properties that may play an important role in preventing neurodegeneration.
American Psychological Association (APA)
Tarozzi, Andrea& Angeloni, Cristina& Malaguti, Marco& Morroni, Fabiana& Hrelia, Silvana& Hrelia, Patrizia. 2013. Sulforaphane as a Potential Protective Phytochemical against Neurodegenerative Diseases. Oxidative Medicine and Cellular Longevity،Vol. 2013, no. 2013, pp.1-10.
https://search.emarefa.net/detail/BIM-470313
Modern Language Association (MLA)
Tarozzi, Andrea…[et al.]. Sulforaphane as a Potential Protective Phytochemical against Neurodegenerative Diseases. Oxidative Medicine and Cellular Longevity No. 2013 (2013), pp.1-10.
https://search.emarefa.net/detail/BIM-470313
American Medical Association (AMA)
Tarozzi, Andrea& Angeloni, Cristina& Malaguti, Marco& Morroni, Fabiana& Hrelia, Silvana& Hrelia, Patrizia. Sulforaphane as a Potential Protective Phytochemical against Neurodegenerative Diseases. Oxidative Medicine and Cellular Longevity. 2013. Vol. 2013, no. 2013, pp.1-10.
https://search.emarefa.net/detail/BIM-470313
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-470313