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Visual Deprivation Decreases Somatic GAD65 Puncta Number on Layer 23 Pyramidal Neurons in Mouse Visual Cortex
Joint Authors
Song, Lihua
Kreczko, Alicja
Goel, Anubhuthi
Lee, Hey-Kyoung
Source
Issue
Vol. 2009, Issue 2009 (31 Dec. 2009), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2009-05-25
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Proper functioning of the visual system depends on maturation of both excitatory and inhibitory synapses within the visual cortex.
Considering that perisomatic inhibition is one of the key factors that control the critical period in visual cortex, it is pertinent to understand its regulation by visual experience.
To do this, we developed an immunohistochemical method that allows three-dimensional (3D) analysis of the glutamic acid decarboxylase (GAD) 65-positive inhibitory terminals in the visual cortex.
Using this method on transgenic mice expressing yellow fluorescence protein (YFP) in a subset of neurons, we found that the number of somatic GAD65-puncta on individual layer 2/3 pyramidal neurons is reduced when mice are dark-reared from birth and reverted to normal levels by re-exposure to light.
There was no change in GAD65-puncta volume or intensity.
These results support the reorganization of inhibitory circuitry within layer 2/3 of visual cortex in response to changes in visual experience.
American Psychological Association (APA)
Kreczko, Alicja& Goel, Anubhuthi& Song, Lihua& Lee, Hey-Kyoung. 2009. Visual Deprivation Decreases Somatic GAD65 Puncta Number on Layer 23 Pyramidal Neurons in Mouse Visual Cortex. Neural Plasticity،Vol. 2009, no. 2009, pp.1-7.
https://search.emarefa.net/detail/BIM-470317
Modern Language Association (MLA)
Kreczko, Alicja…[et al.]. Visual Deprivation Decreases Somatic GAD65 Puncta Number on Layer 23 Pyramidal Neurons in Mouse Visual Cortex. Neural Plasticity No. 2009 (2009), pp.1-7.
https://search.emarefa.net/detail/BIM-470317
American Medical Association (AMA)
Kreczko, Alicja& Goel, Anubhuthi& Song, Lihua& Lee, Hey-Kyoung. Visual Deprivation Decreases Somatic GAD65 Puncta Number on Layer 23 Pyramidal Neurons in Mouse Visual Cortex. Neural Plasticity. 2009. Vol. 2009, no. 2009, pp.1-7.
https://search.emarefa.net/detail/BIM-470317
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-470317