Optimal Fluxes, Reaction Replaceability, and Response to Enzymopathies in the Human Red Blood Cell
Joint Authors
Marinari, E.
Van Kerrebroeck, V.
De Martino, A.
Martelli, C.
Granata, D.
Source
Journal of Biomedicine and Biotechnology
Issue
Vol. 2010, Issue 2010 (31 Dec. 2010), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-06-30
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Characterizing the capabilities, key dependencies, and response to perturbations of genome-scale metabolic networks is a basic problem with important applications.
A key question concerns the identification of the potentially most harmful reaction knockouts.
The integration of combinatorial methods with sampling techniques to explore the space of viable flux states may provide crucial insights on this issue.
We assess the replaceability of every metabolic conversion in the human red blood cell by enumerating the alternative paths from substrate to product, obtaining a complete map of he potential damage of single enzymopathies.
Sampling the space of optimal steady state fluxes in the healthy and in the mutated cell reveals both correlations and complementarity between topologic and dynamical aspects.
American Psychological Association (APA)
De Martino, A.& Granata, D.& Marinari, E.& Martelli, C.& Van Kerrebroeck, V.. 2010. Optimal Fluxes, Reaction Replaceability, and Response to Enzymopathies in the Human Red Blood Cell. Journal of Biomedicine and Biotechnology،Vol. 2010, no. 2010, pp.1-10.
https://search.emarefa.net/detail/BIM-470318
Modern Language Association (MLA)
De Martino, A.…[et al.]. Optimal Fluxes, Reaction Replaceability, and Response to Enzymopathies in the Human Red Blood Cell. Journal of Biomedicine and Biotechnology No. 2010 (2010), pp.1-10.
https://search.emarefa.net/detail/BIM-470318
American Medical Association (AMA)
De Martino, A.& Granata, D.& Marinari, E.& Martelli, C.& Van Kerrebroeck, V.. Optimal Fluxes, Reaction Replaceability, and Response to Enzymopathies in the Human Red Blood Cell. Journal of Biomedicine and Biotechnology. 2010. Vol. 2010, no. 2010, pp.1-10.
https://search.emarefa.net/detail/BIM-470318
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-470318