Mechanisms of Resistance to Trastuzumab and Novel Therapeutic Strategies in HER2-Positive Breast Cancer
Joint Authors
Lee, Soo-Chin
Wong, Andrea L. A.
Source
International Journal of Breast Cancer
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-05-09
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
HER2-positive breast cancers have poorer prognosis and are prime candidates for molecular-targeted therapy because they are driven by the unique mechanism of HER2 oncogene addiction.
While anti-HER2 agents such as trastuzumab and lapatinib are integral to the treatment of HER2-positive breast cancer, intrinsic and secondary resistance pose a significant challenge, underscoring the need to develop novel anti-HER2 therapies.
In recent years, an array of promising and novel anti-HER2 therapeutic agents and their combinations have entered various stages of clinical development.
However, questions remain on the optimal sequences of HER2-directed therapies and selection of patients for the most appropriate drug or combinations; incompletely defined mechanisms of trastuzumab action and resistance have also dampened the progress of more successful biomarker-driven treatment approaches.
This paper summarizes existing preclinical and clinical evidence on the mechanisms of trastuzumab action and resistance and provides an up-to-date overview of novel HER2-directed therapies in clinical development.
American Psychological Association (APA)
Wong, Andrea L. A.& Lee, Soo-Chin. 2012. Mechanisms of Resistance to Trastuzumab and Novel Therapeutic Strategies in HER2-Positive Breast Cancer. International Journal of Breast Cancer،Vol. 2012, no. 2012, pp.1-13.
https://search.emarefa.net/detail/BIM-470322
Modern Language Association (MLA)
Wong, Andrea L. A.& Lee, Soo-Chin. Mechanisms of Resistance to Trastuzumab and Novel Therapeutic Strategies in HER2-Positive Breast Cancer. International Journal of Breast Cancer No. 2012 (2012), pp.1-13.
https://search.emarefa.net/detail/BIM-470322
American Medical Association (AMA)
Wong, Andrea L. A.& Lee, Soo-Chin. Mechanisms of Resistance to Trastuzumab and Novel Therapeutic Strategies in HER2-Positive Breast Cancer. International Journal of Breast Cancer. 2012. Vol. 2012, no. 2012, pp.1-13.
https://search.emarefa.net/detail/BIM-470322
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-470322