Effects of Ubiquinol-10 on MicroRNA-146a Expression In Vitro and In Vivo
Joint Authors
Kitano, Mitsuaki
Menke, Thomas
Hosoe, Kazunori
Rimbach, Gerald
Niklowitz, Petra
Döring, Frank
Schmelzer, Constance
Source
Issue
Vol. 2009, Issue 2009 (31 Dec. 2009), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2009-04-16
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
MicroRNAs (miRs) are involved in key biological processes via suppression of gene expression at posttranscriptional levels.
According to their superior functions, subtle modulation of miR expression by certain compounds or nutrients is desirable under particular conditions.
Bacterial lipopolysaccharide (LPS) induces a reactive oxygen species-/NF-κB-dependent pathway which increases the expression of the anti-inflammatory miR-146a.
We hypothesized that this induction could be modulated by the antioxidant ubiquinol-10.
Preincubation of human monocytic THP-1 cells with ubiquinol-10 reduced the LPS-induced expression level of miR-146a to 78.9 ± 13.22%.
In liver samples of mice injected with LPS, supplementation with ubiquinol-10 leads to a reduction of LPS-induced miR-146a expression to 78.12 ± 21.25%.
From these consistent in vitro and in vivo data, we conclude that ubiquinol-10 may fine-tune the inflammatory response via moderate reduction of miR-146a expression.
American Psychological Association (APA)
Schmelzer, Constance& Kitano, Mitsuaki& Rimbach, Gerald& Niklowitz, Petra& Menke, Thomas& Hosoe, Kazunori…[et al.]. 2009. Effects of Ubiquinol-10 on MicroRNA-146a Expression In Vitro and In Vivo. Mediators of Inflammation،Vol. 2009, no. 2009, pp.1-7.
https://search.emarefa.net/detail/BIM-470349
Modern Language Association (MLA)
Schmelzer, Constance…[et al.]. Effects of Ubiquinol-10 on MicroRNA-146a Expression In Vitro and In Vivo. Mediators of Inflammation No. 2009 (2009), pp.1-7.
https://search.emarefa.net/detail/BIM-470349
American Medical Association (AMA)
Schmelzer, Constance& Kitano, Mitsuaki& Rimbach, Gerald& Niklowitz, Petra& Menke, Thomas& Hosoe, Kazunori…[et al.]. Effects of Ubiquinol-10 on MicroRNA-146a Expression In Vitro and In Vivo. Mediators of Inflammation. 2009. Vol. 2009, no. 2009, pp.1-7.
https://search.emarefa.net/detail/BIM-470349
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-470349