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Unveiling Stability Criteria of DNA-Carbon Nanotubes Constructs by Scanning Tunneling Microscopy and Computational Modeling
Joint Authors
Balatsky, Alexander V.
Kilina, Svetlana
Taylor, Antoinette J.
Talin, A. Alec
Tretiak, Sergei
Yarotski, Dzmitry A.
Source
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-03-20
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
We present a combined approach that relies on computational simulations and scanning tunneling microscopy (STM) measurements to reveal morphological properties and stability criteria of carbon nanotube-DNA (CNT-DNA) constructs.
Application of STM allows direct observation of very stable CNT-DNA hybrid structures with the well-defined DNA wrapping angle of 63.4° and a coiling period of 3.3 nm.
Using force field simulations, we determine how the DNA-CNT binding energy depends on the sequence and binding geometry of a single strand DNA.
This dependence allows us to quantitatively characterize the stability of a hybrid structure with an optimal π-stacking between DNA nucleotides and the tube surface and better interpret STM data.
Our simulations clearly demonstrate the existence of a very stable DNA binding geometry for (6,5) CNT as evidenced by the presence of a well-defined minimum in the binding energy as a function of an angle between DNA strand and the nanotube chiral vector.
This novel approach demonstrates the feasibility of CNT-DNA geometry studies with subnanometer resolution and paves the way towards complete characterization of the structural and electronic properties of drug-delivering systems based on DNA-CNT hybrids as a function of DNA sequence and a nanotube chirality.
American Psychological Association (APA)
Kilina, Svetlana& Yarotski, Dzmitry A.& Talin, A. Alec& Tretiak, Sergei& Taylor, Antoinette J.& Balatsky, Alexander V.. 2011. Unveiling Stability Criteria of DNA-Carbon Nanotubes Constructs by Scanning Tunneling Microscopy and Computational Modeling. Journal of Drug Delivery،Vol. 2011, no. 2011, pp.1-9.
https://search.emarefa.net/detail/BIM-470358
Modern Language Association (MLA)
Kilina, Svetlana…[et al.]. Unveiling Stability Criteria of DNA-Carbon Nanotubes Constructs by Scanning Tunneling Microscopy and Computational Modeling. Journal of Drug Delivery No. 2011 (2011), pp.1-9.
https://search.emarefa.net/detail/BIM-470358
American Medical Association (AMA)
Kilina, Svetlana& Yarotski, Dzmitry A.& Talin, A. Alec& Tretiak, Sergei& Taylor, Antoinette J.& Balatsky, Alexander V.. Unveiling Stability Criteria of DNA-Carbon Nanotubes Constructs by Scanning Tunneling Microscopy and Computational Modeling. Journal of Drug Delivery. 2011. Vol. 2011, no. 2011, pp.1-9.
https://search.emarefa.net/detail/BIM-470358
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-470358