Expression of Stem Cell and Epithelial-Mesenchymal Transition Markers in Circulating Tumor Cells of Breast Cancer Patients
Joint Authors
Ruckhaeberle, Eugen
Meier-Stiegen, Franziska
Banys, Malgorzata
Krawczyk, Natalia
Fehm, Tanja
Neubauer, Hans
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-05-08
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Evaluation and characterization of circulating tumor cells (CTCs) have become a major focus of translational cancer research.
Presence of CTCs predicts worse clinical outcome in early and metastatic breast cancer.
Whether all cells from the primary tumor have potential to disseminate and form subsequent metastasis remains unclear.
As part of the metastatic cascade, tumor cells lose their cell-to-cell adhesion and undergo epithelial-mesenchymal transition (EMT) in order to enter blood circulation.
During EMT epithelial antigens are downregulated; thus, such tumor cells might elude classical epithelial marker-based detection.
Several researchers postulated that some CTCs express stem cell-like phenotype; this might lead to chemoresistance and enhanced metastatic potential of such cells.
In the present review, we discuss current data on EMT and stem cell markers in CTCs of breast cancer and their clinical significance.
American Psychological Association (APA)
Krawczyk, Natalia& Meier-Stiegen, Franziska& Banys, Malgorzata& Neubauer, Hans& Ruckhaeberle, Eugen& Fehm, Tanja. 2014. Expression of Stem Cell and Epithelial-Mesenchymal Transition Markers in Circulating Tumor Cells of Breast Cancer Patients. BioMed Research International،Vol. 2014, no. 2014, pp.1-11.
https://search.emarefa.net/detail/BIM-470374
Modern Language Association (MLA)
Krawczyk, Natalia…[et al.]. Expression of Stem Cell and Epithelial-Mesenchymal Transition Markers in Circulating Tumor Cells of Breast Cancer Patients. BioMed Research International No. 2014 (2014), pp.1-11.
https://search.emarefa.net/detail/BIM-470374
American Medical Association (AMA)
Krawczyk, Natalia& Meier-Stiegen, Franziska& Banys, Malgorzata& Neubauer, Hans& Ruckhaeberle, Eugen& Fehm, Tanja. Expression of Stem Cell and Epithelial-Mesenchymal Transition Markers in Circulating Tumor Cells of Breast Cancer Patients. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-11.
https://search.emarefa.net/detail/BIM-470374
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-470374