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Thrombin A-Chain : Activation Remnant or Allosteric Effector?
Joint Authors
Carter, Isis S. R.
Pryzdial, Edward L. G.
MacGillivray, Ross T. A.
Vanden Hoek, Amanda L.
Source
Issue
Vol. 2010, Issue 2010 (31 Dec. 2010), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-12-09
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Although prothrombin is one of the most widely studied enzymes in biology, the role of the thrombin A-chain has been neglected in comparison to the other domains.
This paper summarizes the current data on the prothrombin catalytic domain A-chain region and the subsequent thrombin A-chain.
Attention is given to biochemical characterization of naturally occurring prothrombin A-chain mutations and alanine scanning mutants in this region.
While originally considered to be simply an activation remnant with little physiologic function, the thrombin A-chain is now thought to play a role as an allosteric effector in enzymatic reactions and may also be a structural scaffold to stabilize the protease domain.
American Psychological Association (APA)
Carter, Isis S. R.& Vanden Hoek, Amanda L.& Pryzdial, Edward L. G.& MacGillivray, Ross T. A.. 2010. Thrombin A-Chain : Activation Remnant or Allosteric Effector?. Thrombosis،Vol. 2010, no. 2010, pp.1-9.
https://search.emarefa.net/detail/BIM-470423
Modern Language Association (MLA)
Carter, Isis S. R.…[et al.]. Thrombin A-Chain : Activation Remnant or Allosteric Effector?. Thrombosis No. 2010 (2010), pp.1-9.
https://search.emarefa.net/detail/BIM-470423
American Medical Association (AMA)
Carter, Isis S. R.& Vanden Hoek, Amanda L.& Pryzdial, Edward L. G.& MacGillivray, Ross T. A.. Thrombin A-Chain : Activation Remnant or Allosteric Effector?. Thrombosis. 2010. Vol. 2010, no. 2010, pp.1-9.
https://search.emarefa.net/detail/BIM-470423
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-470423