Suppression of Proinflammatory Cytokines in Functionalized Fullerene-Exposed Dermal Keratinocytes
Joint Authors
Wang, Hsing-Lin
Gao, Jun
Iyer, Rashi
Source
Issue
Vol. 2010, Issue 2010 (31 Dec. 2010), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-02-28
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Engineering Sciences and Information Technology
Chemistry
Civil Engineering
Abstract EN
Initial experiments using differentially functionalized fullerenes, CD-C60, hexa-C60, and tris-C60, suggested a properties dependent effect on cytotoxic and proliferative responses in human skin keratinocytes.
In the present study we investigated the cytokine secretion profile of dermal epithelial cells exposed to functionalized fullerenes.
Keratinocyte-derived cytokines affect homing and trafficking of normal and malignant epidermal immune as well as nonimmune cells in vivo.
These cytokines are critical for regulating activation, proliferation, and differentiation of epidermal cells.
Our results indicate that tris-C60 (size range <100 nm) significantly reduces inflammatory cytokine release in a dose- and time-dependent manner.
In contrast CD-C60 demonstrated a relatively pro-inflammatory cytokine response, while hexa-C60 did not significantly perturb cytokine responses.
Physical and chemical characterizations of these engineered nanomaterials suggest that the disparate biological responses observed may potentially be a function of the aggregation properties of these fullerenes.
American Psychological Association (APA)
Gao, Jun& Wang, Hsing-Lin& Iyer, Rashi. 2010. Suppression of Proinflammatory Cytokines in Functionalized Fullerene-Exposed Dermal Keratinocytes. Journal of Nanomaterials،Vol. 2010, no. 2010, pp.1-9.
https://search.emarefa.net/detail/BIM-470447
Modern Language Association (MLA)
Gao, Jun…[et al.]. Suppression of Proinflammatory Cytokines in Functionalized Fullerene-Exposed Dermal Keratinocytes. Journal of Nanomaterials No. 2010 (2010), pp.1-9.
https://search.emarefa.net/detail/BIM-470447
American Medical Association (AMA)
Gao, Jun& Wang, Hsing-Lin& Iyer, Rashi. Suppression of Proinflammatory Cytokines in Functionalized Fullerene-Exposed Dermal Keratinocytes. Journal of Nanomaterials. 2010. Vol. 2010, no. 2010, pp.1-9.
https://search.emarefa.net/detail/BIM-470447
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-470447