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The Sound of Silence : Mouse Models for Hearing Loss
Joint Authors
Chatterjee, Sumantra
Lufkin, Thomas
Source
Genetics Research International
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-10-09
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Sensorineural hearing loss is one of the most common disabilities in humans.
It is estimated that about 278 million people worldwide have slight to extreme hearing loss in both ears, which results in an economic loss for the country and personal loss for the individual.
It is thus critical to have a deeper understanding of the causes for hearing loss to better manage and treat the affected individuals.
The mouse serves as an excellent model to study and recapitulate some of these phenotypes, identify new genes which cause deafness, and to study their roles in vivo and in detail.
Mutant mice have been instrumental in elucidating the function and mechanisms of the inner ear.
The development and morphogenesis of the inner ear from an ectodermal layer into distinct auditory and vestibular components depends on well-coordinated gene expression and well-orchestrated signaling cascades within the otic vesicle and interactions with surrounding layers of tissues.
Any disruption in these pathways can lead to hearing impairment.
This review takes a look at some of the genes and their corresponding mice mutants that have shed light on the mechanism governing hearing impairment (HI) in humans.
American Psychological Association (APA)
Chatterjee, Sumantra& Lufkin, Thomas. 2011. The Sound of Silence : Mouse Models for Hearing Loss. Genetics Research International،Vol. 2011, no. 2011, pp.1-9.
https://search.emarefa.net/detail/BIM-470453
Modern Language Association (MLA)
Chatterjee, Sumantra& Lufkin, Thomas. The Sound of Silence : Mouse Models for Hearing Loss. Genetics Research International No. 2011 (2011), pp.1-9.
https://search.emarefa.net/detail/BIM-470453
American Medical Association (AMA)
Chatterjee, Sumantra& Lufkin, Thomas. The Sound of Silence : Mouse Models for Hearing Loss. Genetics Research International. 2011. Vol. 2011, no. 2011, pp.1-9.
https://search.emarefa.net/detail/BIM-470453
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-470453