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Comparison of Host Immune Responses to Homologous and Heterologous Type II Porcine Reproductive and Respiratory Syndrome Virus (PRRSV) Challenge in Vaccinated and Unvaccinated Pigs
Joint Authors
Nietfeld, J. C.
Shi, J.
Blecha, F.
Pappan, L.
Trible, B.
Hesse, R.
Beck, A.
Kerrigan, M.
Rowland, Raymond R. R.
Galliher-Beckley, A.
Li, X.
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-02-26
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Porcine reproductive and respiratory syndrome (PRRS) is a high-consequence animal disease with current vaccines providing limited protection from infection due to the high degree of genetic variation of field PRRS virus.
Therefore, understanding host immune responses elicited by different PRRSV strains will facilitate the development of more effective vaccines.
Using IngelVac modified live PRRSV vaccine (MLV), its parental strain VR-2332, and the heterologous KS-06-72109 strain (a Kansas isolate of PRRSV), we compared immune responses induced by vaccination and/or PRRSV infection.
Our results showed that MLV can provide complete protection from homologous virus (VR-2332) and partial protection from heterologous (KS-06) challenge.
The protection was associated with the levels of PRRSV neutralizing antibodies at the time of challenge, with vaccinated pigs having higher titers to VR-2332 compared to KS-06 strain.
Challenge strain did not alter the cytokine expression profiles in the serum of vaccinated pigs or subpopulations of T cells.
However, higher frequencies of IFN-γ-secreting PBMCs were generated from pigs challenged with heterologous PRRSV in a recall response when PBMCs were re-stimulated with PRRSV.
Thus, this study indicates that serum neutralizing antibody titers are associated with PRRSV vaccination-induced protection against homologous and heterologous challenge.
American Psychological Association (APA)
Li, X.& Galliher-Beckley, A.& Pappan, L.& Trible, B.& Kerrigan, M.& Beck, A.…[et al.]. 2014. Comparison of Host Immune Responses to Homologous and Heterologous Type II Porcine Reproductive and Respiratory Syndrome Virus (PRRSV) Challenge in Vaccinated and Unvaccinated Pigs. BioMed Research International،Vol. 2014, no. 2014, pp.1-10.
https://search.emarefa.net/detail/BIM-470469
Modern Language Association (MLA)
Li, X.…[et al.]. Comparison of Host Immune Responses to Homologous and Heterologous Type II Porcine Reproductive and Respiratory Syndrome Virus (PRRSV) Challenge in Vaccinated and Unvaccinated Pigs. BioMed Research International No. 2014 (2014), pp.1-10.
https://search.emarefa.net/detail/BIM-470469
American Medical Association (AMA)
Li, X.& Galliher-Beckley, A.& Pappan, L.& Trible, B.& Kerrigan, M.& Beck, A.…[et al.]. Comparison of Host Immune Responses to Homologous and Heterologous Type II Porcine Reproductive and Respiratory Syndrome Virus (PRRSV) Challenge in Vaccinated and Unvaccinated Pigs. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-10.
https://search.emarefa.net/detail/BIM-470469
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-470469