Preventive Treatment with Methylprednisolone Paradoxically Exacerbates Experimental Autoimmune Encephalomyelitis
Joint Authors
Lühder, Fred
Wüst, Simone
van den Brandt, Jens
Reichardt, Holger M.
Source
International Journal of Endocrinology
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-11-29
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Glucocorticoids (GCs) represent the standard treatment for acute disease bouts in multiple sclerosis (MS) patients, for which methylprednisolone (MP) pulse therapy is the most frequently used protocol.
Here, we compared the efficacy of therapeutic and preventive MP application in MOG35-55-induced experimental autoimmune encephalomyelitis (EAE) in C57Bl/6 mice.
When administered briefly after the onset of the disease, MP efficiently ameliorated EAE in a dose-dependent manner.
Surprisingly, MP administration around the time of immunization was contraindicated as it even increased leukocyte infiltration into the CNS and worsened the disease symptoms.
Our analyses suggest that in the latter case an incomplete depletion of peripheral T cells by MP triggers homeostatic proliferation, which presumably results in an enhanced priming of autoreactive T cells and causes an aggravated disease course.
Thus, the timing and selection of a particular GC derivative require careful consideration in MS therapy.
American Psychological Association (APA)
Wüst, Simone& van den Brandt, Jens& Reichardt, Holger M.& Lühder, Fred. 2012. Preventive Treatment with Methylprednisolone Paradoxically Exacerbates Experimental Autoimmune Encephalomyelitis. International Journal of Endocrinology،Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-470503
Modern Language Association (MLA)
Wüst, Simone…[et al.]. Preventive Treatment with Methylprednisolone Paradoxically Exacerbates Experimental Autoimmune Encephalomyelitis. International Journal of Endocrinology No. 2012 (2012), pp.1-8.
https://search.emarefa.net/detail/BIM-470503
American Medical Association (AMA)
Wüst, Simone& van den Brandt, Jens& Reichardt, Holger M.& Lühder, Fred. Preventive Treatment with Methylprednisolone Paradoxically Exacerbates Experimental Autoimmune Encephalomyelitis. International Journal of Endocrinology. 2012. Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-470503
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-470503