Osteosarcoma Models : From Cell Lines to Zebrafish
Joint Authors
Hogendoorn, Pancras C. W.
Cleton-Jansen, Anne-Marie
Mohseny, Alexander B.
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-03-15
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
High-grade osteosarcoma is an aggressive tumor most commonly affecting adolescents.
The early age of onset might suggest genetic predisposition; however, the vast majority of the tumors are sporadic.
Early onset, most often lack of a predisposing condition or lesion, only infrequent (<2%) prevalence of inheritance, extensive genomic instability, and a wide histological heterogeneity are just few factors to mention that make osteosarcoma difficult to study.
Therefore, it is sensible to design and use models representative of the human disease.
Here we summarize multiple osteosarcoma models established in vitro and in vivo, comment on their utilities, and highlight newest achievements, such as the use of zebrafish embryos.
We conclude that to gain a better understanding of osteosarcoma, simplification of this extremely complex tumor is needed.
Therefore, we parse the osteosarcoma problem into parts and propose adequate models to study them each separately.
A better understanding of osteosarcoma provides opportunities for discovering and assaying novel effective treatment strategies.
American Psychological Association (APA)
Mohseny, Alexander B.& Hogendoorn, Pancras C. W.& Cleton-Jansen, Anne-Marie. 2012. Osteosarcoma Models : From Cell Lines to Zebrafish. Sarcoma،Vol. 2012, no. 2012, pp.1-11.
https://search.emarefa.net/detail/BIM-470528
Modern Language Association (MLA)
Mohseny, Alexander B.…[et al.]. Osteosarcoma Models : From Cell Lines to Zebrafish. Sarcoma No. 2012 (2012), pp.1-11.
https://search.emarefa.net/detail/BIM-470528
American Medical Association (AMA)
Mohseny, Alexander B.& Hogendoorn, Pancras C. W.& Cleton-Jansen, Anne-Marie. Osteosarcoma Models : From Cell Lines to Zebrafish. Sarcoma. 2012. Vol. 2012, no. 2012, pp.1-11.
https://search.emarefa.net/detail/BIM-470528
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-470528