Serum Levels of Biochemical Markers of Traumatic Brain Injury
Joint Authors
Borg, Keith
Sawadsky, Bruce
Stanton, Eric B.
Kupchak, Peter
Jauch, Edward C.
Bonomo, Jordan B.
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-01-19
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Background.
A biomarker would be valuable in the diagnosis, risk stratification and prognosis of patients with traumatic brain injury (TBI).
Methods.
We measured serum levels of S-100β, neuron specific enolase (NSE) and myelin basic protein (MBP) in 50 TBI subjects, and 50 age and gender matched controls.
Patients were recruited within 6 hours of the initial injury, they had an initial Glasgow Coma Scale (GCS) score of 14 or less, or a GCS score of 15 with witnessed loss of consciousness (LOC) or amnesia.
Results.
S-100β, NSE and MBP levels were significantly higher in TBI subjects than in control subjects (P<0.001 for S-100β and NSE; P=0.009 for MBP).
Initial S-100β levels were significantly higher in TBI subjects who had not retuned to normal activities 2 weeks following their injury than in TBI subjects who had retuned to normal activities (P=0.022).
MBP levels were higher in TBI subjects with positive findings on the baseline CT scan than in CT-negative subjects (P=0.007).
Conclusions.
S-100β, NSE and MBP may be present in the sera of TBI subjects in elevated quantities relative to controls.
S-100β may aid in predicting short-term outcome in TBI subjects.
American Psychological Association (APA)
Borg, Keith& Bonomo, Jordan B.& Jauch, Edward C.& Kupchak, Peter& Stanton, Eric B.& Sawadsky, Bruce. 2012. Serum Levels of Biochemical Markers of Traumatic Brain Injury. ISRN Emergency Medicine،Vol. 2012, no. 2012, pp.1-7.
https://search.emarefa.net/detail/BIM-470532
Modern Language Association (MLA)
Borg, Keith…[et al.]. Serum Levels of Biochemical Markers of Traumatic Brain Injury. ISRN Emergency Medicine No. 2012 (2012), pp.1-7.
https://search.emarefa.net/detail/BIM-470532
American Medical Association (AMA)
Borg, Keith& Bonomo, Jordan B.& Jauch, Edward C.& Kupchak, Peter& Stanton, Eric B.& Sawadsky, Bruce. Serum Levels of Biochemical Markers of Traumatic Brain Injury. ISRN Emergency Medicine. 2012. Vol. 2012, no. 2012, pp.1-7.
https://search.emarefa.net/detail/BIM-470532
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-470532