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Peroxisome Proliferator-Activated Receptors Protect against Apoptosis via 14-3-3
Author
Source
Issue
Vol. 2010, Issue 2010 (31 Dec. 2010), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-08-24
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Natural & Life Sciences (Multidisciplinary)
Biology
Abstract EN
Peroxisome proliferator-activated receptors (PPARs) were reported to prevent cells from stress-induced apoptosis and protect tissues against ischemia-reperfusion injury.
The underlying transcriptional mechanism is unclear.
Recent reports indicate that the antiapoptotic actions of ligand-activated PPARδ and PPARγ are mediated through enhanced binding of PPAR to the promoter of 14-3-3ε and upregulation of 14-3-3ε expression.
We propose that ligand-activated PPARα exerts its anti-apoptotic actions via the identical pathway.
The PPAR to 14-3-3 transcriptional axis plays an important role in protection of cell and tissue integrity and is a target for drug discovery.
American Psychological Association (APA)
Wu, Kenneth K.. 2010. Peroxisome Proliferator-Activated Receptors Protect against Apoptosis via 14-3-3. PPAR Research،Vol. 2010, no. 2010, pp.1-7.
https://search.emarefa.net/detail/BIM-470559
Modern Language Association (MLA)
Wu, Kenneth K.. Peroxisome Proliferator-Activated Receptors Protect against Apoptosis via 14-3-3. PPAR Research No. 2010 (2010), pp.1-7.
https://search.emarefa.net/detail/BIM-470559
American Medical Association (AMA)
Wu, Kenneth K.. Peroxisome Proliferator-Activated Receptors Protect against Apoptosis via 14-3-3. PPAR Research. 2010. Vol. 2010, no. 2010, pp.1-7.
https://search.emarefa.net/detail/BIM-470559
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-470559