Persistently Elevated Level of IL-8 in Chlamydia trachomatis Infected HeLa 229 Cells is Dependent on Intracellular Available Iron
Joint Authors
Jha, Hem Chandra
Srivastava, Pragya
Mittal, Aruna Singh
Vardhan, Harsh
Gupta, Rishein
Bhengraj, Apurb Rashmi
Jha, Rajneesh
Vats, Vikas
Dutta, Raini
Source
Issue
Vol. 2009, Issue 2009 (31 Dec. 2009), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2009-05-26
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Chlamydia trachomatis is a leading cause of sexually transmitted infection worldwide and responsible for myriad of immunopathological changes associated with reproductive health.
Delayed secretion of proinflammatory chemokine interleukin (IL)-8 is a hallmark of chlamydial infection and is dependent on chlamydial growth.
We examined the effect of iron chelators on IL-8 production in HeLa 229 (cervix epitheloid cell, CCL2) cells infected with C.
trachomatis.
IL-8 production was induced by Iron chelator DFO and Mimosine, however, synergy with chlamydial infection was obtained with DFO only.
Temporal expression of proinflammatory secreted cytokines IL-1beta, TNF-alpha, and IL-8 did not show synchrony in Chlamydia trachomatis infected cells.
Secretion of IL-8 from Hela cells infected with C.
trachomatis was not dependent on IL-1 beta and TNF- alpha induction.
These results indicate towards involvement of iron in chlamydia induced IL-8 production.
American Psychological Association (APA)
Vardhan, Harsh& Dutta, Raini& Vats, Vikas& Gupta, Rishein& Jha, Rajneesh& Jha, Hem Chandra…[et al.]. 2009. Persistently Elevated Level of IL-8 in Chlamydia trachomatis Infected HeLa 229 Cells is Dependent on Intracellular Available Iron. Mediators of Inflammation،Vol. 2009, no. 2009, pp.1-6.
https://search.emarefa.net/detail/BIM-470562
Modern Language Association (MLA)
Vardhan, Harsh…[et al.]. Persistently Elevated Level of IL-8 in Chlamydia trachomatis Infected HeLa 229 Cells is Dependent on Intracellular Available Iron. Mediators of Inflammation No. 2009 (2009), pp.1-6.
https://search.emarefa.net/detail/BIM-470562
American Medical Association (AMA)
Vardhan, Harsh& Dutta, Raini& Vats, Vikas& Gupta, Rishein& Jha, Rajneesh& Jha, Hem Chandra…[et al.]. Persistently Elevated Level of IL-8 in Chlamydia trachomatis Infected HeLa 229 Cells is Dependent on Intracellular Available Iron. Mediators of Inflammation. 2009. Vol. 2009, no. 2009, pp.1-6.
https://search.emarefa.net/detail/BIM-470562
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-470562
