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Phytochemicals from Kaempferia angustifolia Rosc. and Their Cytotoxic and Antimicrobial Activities
Joint Authors
Cheng Lian Ee, Gwendoline
Kifli, Nurolaini
Sukari, Mohd Aspollah
Neoh, Bee Keat
Abdul, Ahmad Bustamam
Yeap, Yunie Soon Yu
Tang, Sook Wah
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-06-25
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Phytochemical investigation on rhizomes of Kaempferia angustifolia has afforded a new abietene diterpene, kaempfolienol (1) along with crotepoxide (2), boesenboxide (3), 2′-hydroxy-4,4′,6′-trimethoxychalcone (4), zeylenol (5), 6-methylzeylenol (6), (24S)-24-methyl-5α-lanosta-9(11), 25-dien-3β-ol (7), sucrose, β-sitosterol, and its glycoside (8).
The structures of the compounds were elucidated on the basis of spectroscopic methods (IR, MS, and NMR).
Isolation of 6-methylzeylenol (6), (24S)-24-methyl-5α-lanosta-9(11), 25-dien-3β-ol (7), and β-sitosterol-3-O-β-D-glucopyranoside (8) from this plant species has never been reported previously.
The spectroscopic data of (7) is firstly described in this paper.
Cytotoxic screening indicated that most of the pure compounds tested showed significant activity with (4) showing the most potent activity against HL-60 (human promyelocytic leukemia) and MCF-7 (human breast cancer) cell lines.
However, all extracts and most of the pure compounds tested were found to be inactive against HT-29 (human colon cancer) and HeLa (human cervical cancer) cell lines.
Similarly, none of the extracts or compounds showed activity in the antimicrobial testing.
American Psychological Association (APA)
Tang, Sook Wah& Sukari, Mohd Aspollah& Neoh, Bee Keat& Yeap, Yunie Soon Yu& Abdul, Ahmad Bustamam& Kifli, Nurolaini…[et al.]. 2014. Phytochemicals from Kaempferia angustifolia Rosc. and Their Cytotoxic and Antimicrobial Activities. BioMed Research International،Vol. 2014, no. 2014, pp.1-6.
https://search.emarefa.net/detail/BIM-470564
Modern Language Association (MLA)
Tang, Sook Wah…[et al.]. Phytochemicals from Kaempferia angustifolia Rosc. and Their Cytotoxic and Antimicrobial Activities. BioMed Research International No. 2014 (2014), pp.1-6.
https://search.emarefa.net/detail/BIM-470564
American Medical Association (AMA)
Tang, Sook Wah& Sukari, Mohd Aspollah& Neoh, Bee Keat& Yeap, Yunie Soon Yu& Abdul, Ahmad Bustamam& Kifli, Nurolaini…[et al.]. Phytochemicals from Kaempferia angustifolia Rosc. and Their Cytotoxic and Antimicrobial Activities. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-6.
https://search.emarefa.net/detail/BIM-470564
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-470564