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Skin Autofluorescence, as Marker of Accumulation of Advanced Glycation Endproducts and of Cumulative Metabolic Stress, Is Not Increased in Patients with Systemic Sclerosis
Joint Authors
Smit, A. J.
Hettema, M. E.
Graaff, R.
de Vries, R.
Kallenberg, C. G. M.
Bootsma, H.
Source
International Journal of Rheumatology
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-09-29
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Objective.
To investigate whether advanced glycation endproducts (AGEs) in the skin are increased in patients with systemic sclerosis (SSc) and are related to the presence of disease-related and traditional cardiovascular risk factors.
Methods.
Skin autofluorescence, as a measure for the accumulation of AGEs, was assessed by measuring UV-A light excitation-emission matrices (AF-EEMS) in 41 SSc patients and 41 age- and sex-matched controls.
Traditional cardiovascular risk factors and disease-related risk factors were recorded.
Results.
Skin AF-EEMS did not differ between SSc patients and controls (1.68±0.58 a.u.
versus 1.63±0.41 a.u., P=0.684).
Skin AF-EEMS in SSc patients was associated with levels of CRP (r=0.44, P=0.004), Medsger's severity scale (r=0.45, P=0.006), and use of agents intervening in the renin-angiotensin system (r=0.33, P=0.027).
When analysing SSc patients and controls together, in multivariate analysis, only age and use of agents intervening in the renin-angiotensin system were independently associated with AF-EEMS.
Conclusion.
These data demonstrate that skin AGEs are not increased in SSc patients.
American Psychological Association (APA)
Hettema, M. E.& Bootsma, H.& Graaff, R.& de Vries, R.& Kallenberg, C. G. M.& Smit, A. J.. 2011. Skin Autofluorescence, as Marker of Accumulation of Advanced Glycation Endproducts and of Cumulative Metabolic Stress, Is Not Increased in Patients with Systemic Sclerosis. International Journal of Rheumatology،Vol. 2011, no. 2011, pp.1-6.
https://search.emarefa.net/detail/BIM-470571
Modern Language Association (MLA)
Hettema, M. E.…[et al.]. Skin Autofluorescence, as Marker of Accumulation of Advanced Glycation Endproducts and of Cumulative Metabolic Stress, Is Not Increased in Patients with Systemic Sclerosis. International Journal of Rheumatology No. 2011 (2011), pp.1-6.
https://search.emarefa.net/detail/BIM-470571
American Medical Association (AMA)
Hettema, M. E.& Bootsma, H.& Graaff, R.& de Vries, R.& Kallenberg, C. G. M.& Smit, A. J.. Skin Autofluorescence, as Marker of Accumulation of Advanced Glycation Endproducts and of Cumulative Metabolic Stress, Is Not Increased in Patients with Systemic Sclerosis. International Journal of Rheumatology. 2011. Vol. 2011, no. 2011, pp.1-6.
https://search.emarefa.net/detail/BIM-470571
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-470571