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Preparation and Evaluation of Valsartan Liquid Filling Formulations for Soft Gels
Joint Authors
Sunkara, Seetha
Deekonda, Sravanthi
Nalluri, Buchi N.
Sanaboina, Jyothi
Maheswari, K. M.
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-01-17
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Pharmacy, Health & Medical Sciences
Economics & Business Administration
Pharmacology
Abstract EN
The present investigation includes the preparation of liquid filling formulations for soft gels using an antihypertensive drug, valsartan (VAL), in order to improve its dissolution properties and thereby its bioavailability.
Formulations were prepared using excipients like polyethylene glycol 400 (PEG 400), propylene glycol (PG), polyvinylpyrrolidone (PVP K-30), antioxidants, ethanol, and purified water.
Prepared formulations were evaluated for appearance, pH, drug content percentage, viscosity, stability, and in vitro dissolution studies.
The compatibility between the drug and excipients in formulations was confirmed by FTIR spectra.
The drug contents were in the range of 99.62-99.63 and the viscosity was in the range of 60.9–591.7 cps with all the formulations developed.
Formulations containing 10 mg PVP K 30 gave better dissolution properties when compared to formulations without PVP K 30, and a complete drug dissolution was observed within 10 min and followed the first-order release kinetics.
Stability studies were conducted for selected formulations (F4–F9) for a period of 6 months at room temperature (~30°C/65% RH).
From the studies, it can be concluded that VAL liquid filling formulations for soft gels were successfully prepared with in vitro dissolution properties superior when compared to VAL itself.
American Psychological Association (APA)
Sanaboina, Jyothi& Maheswari, K. M.& Sunkara, Seetha& Deekonda, Sravanthi& Nalluri, Buchi N.. 2013. Preparation and Evaluation of Valsartan Liquid Filling Formulations for Soft Gels. Journal of Pharmaceutics،Vol. 2013, no. 2013, pp.1-8.
https://search.emarefa.net/detail/BIM-470636
Modern Language Association (MLA)
Sanaboina, Jyothi…[et al.]. Preparation and Evaluation of Valsartan Liquid Filling Formulations for Soft Gels. Journal of Pharmaceutics No. 2013 (2013), pp.1-8.
https://search.emarefa.net/detail/BIM-470636
American Medical Association (AMA)
Sanaboina, Jyothi& Maheswari, K. M.& Sunkara, Seetha& Deekonda, Sravanthi& Nalluri, Buchi N.. Preparation and Evaluation of Valsartan Liquid Filling Formulations for Soft Gels. Journal of Pharmaceutics. 2013. Vol. 2013, no. 2013, pp.1-8.
https://search.emarefa.net/detail/BIM-470636
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-470636