Novel BRAF Alteration in a Sporadic Pilocytic Astrocytoma
Joint Authors
Leonard, Jeffrey R.
Yu, Jinsheng
Gutmann, David H.
Dahiya, Sonika
Kaul, Aparna
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-4, 4 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-04-03
Country of Publication
Egypt
No. of Pages
4
Main Subjects
Abstract EN
Pilocytic astrocytoma (PA) is the most frequently encountered glial tumor (glioma or astrocytoma) in children.
Recent studies have identified alterations in the BRAF serine/threonine kinase gene as the likely causative mutation in these childhood brain tumors.
The majority of these genetic changes involve chromosome 7q34 tandem duplication, resulting in aberrant BRAF fusion transcripts.
In this paper, we describe a novel KIAA1549:BRAF fusion transcript in a sporadic PA tumor associated with increased ERK activation and review the spectrum of BRAF genetic alterations in this common pediatric low-grade central nervous system neoplasm.
American Psychological Association (APA)
Dahiya, Sonika& Yu, Jinsheng& Kaul, Aparna& Leonard, Jeffrey R.& Gutmann, David H.. 2012. Novel BRAF Alteration in a Sporadic Pilocytic Astrocytoma. Case Reports in Medicine،Vol. 2012, no. 2012, pp.1-4.
https://search.emarefa.net/detail/BIM-470666
Modern Language Association (MLA)
Dahiya, Sonika…[et al.]. Novel BRAF Alteration in a Sporadic Pilocytic Astrocytoma. Case Reports in Medicine No. 2012 (2012), pp.1-4.
https://search.emarefa.net/detail/BIM-470666
American Medical Association (AMA)
Dahiya, Sonika& Yu, Jinsheng& Kaul, Aparna& Leonard, Jeffrey R.& Gutmann, David H.. Novel BRAF Alteration in a Sporadic Pilocytic Astrocytoma. Case Reports in Medicine. 2012. Vol. 2012, no. 2012, pp.1-4.
https://search.emarefa.net/detail/BIM-470666
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-470666
