Effects of Parathyroid Hormone on Immune Function
Joint Authors
Geara, Abdallah Sassine
Schuller-Levis, Georgia
Smith, Marianne
Elsayegh, Suzanne
Park, Eunkue
Castellanos, Mario R.
Bassil, Claude
Goldman, Michael
Source
Clinical and Developmental Immunology
Issue
Vol. 2010, Issue 2010 (31 Dec. 2010), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-09-16
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Parathyroid hormone (PTH) function as immunologic mediator has become interesting with the recent usage of PTH analogue (teriparatide) in the management of osteoporosis.
Since the early 1980s, PTH receptors were found on most immunologic cells (neutrophils, B and T cells).
The in vitro evaluations for a possible role of PTH as immunomodulator have shown inconsistent results mainly due to methodological heterogeneity of these studies: it used different PTH formulations (rat, bovine, and human), at different dosages and different incubating periods.
In some of these studies, the lymphocytes were collected from uremic patients or animals, which renders the interpretation of the results problematic due to the effect of uremic toxins.
Parathyroidectomy has been found to reverse the immunologic defect in patients with high PTH levels.
Nonetheless, the clinical significance of these findings is unclear.
Further studies are needed to define if PTH does have immunomodulatory effects.
American Psychological Association (APA)
Geara, Abdallah Sassine& Castellanos, Mario R.& Bassil, Claude& Schuller-Levis, Georgia& Park, Eunkue& Smith, Marianne…[et al.]. 2010. Effects of Parathyroid Hormone on Immune Function. Clinical and Developmental Immunology،Vol. 2010, no. 2010, pp.1-10.
https://search.emarefa.net/detail/BIM-470668
Modern Language Association (MLA)
Geara, Abdallah Sassine…[et al.]. Effects of Parathyroid Hormone on Immune Function. Clinical and Developmental Immunology No. 2010 (2010), pp.1-10.
https://search.emarefa.net/detail/BIM-470668
American Medical Association (AMA)
Geara, Abdallah Sassine& Castellanos, Mario R.& Bassil, Claude& Schuller-Levis, Georgia& Park, Eunkue& Smith, Marianne…[et al.]. Effects of Parathyroid Hormone on Immune Function. Clinical and Developmental Immunology. 2010. Vol. 2010, no. 2010, pp.1-10.
https://search.emarefa.net/detail/BIM-470668
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-470668