B7-H4 Pathway in Islet Transplantation and β-Cell Replacement Therapies
Joint Authors
Warnock, Garth L.
Ao, Ziliang
Wang, Xiaojie
Verchere, C. Bruce
Mui, Alice
Ou, Dawei
Hao, Jianqiang
Meloche, Mark
Metzger, Daniel L.
Chen, Lieping
Source
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-10-13
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Type 1 diabetes (T1D) is a chronic autoimmune disease and characterized by absolute insulin deficiency.
β-cell replacement by islet cell transplantation has been established as a feasible treatment option for T1D.
The two main obstacles after islet transplantation are alloreactive T-cell-mediated graft rejection and recurrence of autoimmune diabetes mellitus in recipients.
T cells play a central role in determining the outcome of both autoimmune responses and allograft survival.
B7-H4, a newly identified B7 homolog, plays a key role in maintaining T-cell homeostasis by reducing T-cell proliferation and cytokine production.
The relationship between B7-H4 and allograft survival/autoimmunity has been investigated recently in both islet transplantation and the nonobese diabetic (NOD) mouse models.
B7-H4 protects allograft survival and generates donor-specific tolerance.
It also prevents the development of autoimmune diabetes.
More importantly, B7-H4 plays an indispensable role in alloimmunity in the absence of the classic CD28/CTLA-4 : B7 pathway, suggesting a synergistic/additive effect with other agents such as CTLA-4 on inhibition of unwanted immune responses.
American Psychological Association (APA)
Wang, Xiaojie& Hao, Jianqiang& Metzger, Daniel L.& Ao, Ziliang& Meloche, Mark& Verchere, C. Bruce…[et al.]. 2011. B7-H4 Pathway in Islet Transplantation and β-Cell Replacement Therapies. Journal of Transplantation،Vol. 2011, no. 2011, pp.1-8.
https://search.emarefa.net/detail/BIM-470685
Modern Language Association (MLA)
Wang, Xiaojie…[et al.]. B7-H4 Pathway in Islet Transplantation and β-Cell Replacement Therapies. Journal of Transplantation No. 2011 (2011), pp.1-8.
https://search.emarefa.net/detail/BIM-470685
American Medical Association (AMA)
Wang, Xiaojie& Hao, Jianqiang& Metzger, Daniel L.& Ao, Ziliang& Meloche, Mark& Verchere, C. Bruce…[et al.]. B7-H4 Pathway in Islet Transplantation and β-Cell Replacement Therapies. Journal of Transplantation. 2011. Vol. 2011, no. 2011, pp.1-8.
https://search.emarefa.net/detail/BIM-470685
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-470685