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The Role of Chemotherapy in Upper Tract Urothelial Carcinoma
Joint Authors
Stadler, Walter M.
O'Donnell, Peter H.
Source
Issue
Vol. 2009, Issue 2009 (31 Dec. 2009), pp.1-4, 4 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2009-01-26
Country of Publication
Egypt
No. of Pages
4
Main Subjects
Abstract EN
Locally advanced upper tract urothelial carcinoma has a poor prognosis.
While surgery represents the only potentially curable therapeutic intervention, recurrences are common and typically systemic in nature.
It is thus reasonable to consider perioperative chemotherapy in an effort to decrease the risk of recurrence.
There are very little direct data providing clinical guidance in this scenario.
For urothelial cancer of the bladder, there are randomized phase III data demonstrating a survival advantage with neoadjuvant cisplatin-based combination chemotherapy.
Although arguments favoring adjuvant chemotherapy could be made for upper tract urothelial cancer, the loss of renal function that occurs with nephrectomy can complicate administration of appropriate perioperative treatment.
Therefore, by analogy to urothelial carcinoma of the lower tract, it is argued that cisplatin-based neoadjuvant chemotherapy should be the standard of care for patients with locally advanced upper tract urothelial cancer.
American Psychological Association (APA)
O'Donnell, Peter H.& Stadler, Walter M.. 2009. The Role of Chemotherapy in Upper Tract Urothelial Carcinoma. Advances in Urology،Vol. 2009, no. 2009, pp.1-4.
https://search.emarefa.net/detail/BIM-470698
Modern Language Association (MLA)
O'Donnell, Peter H.& Stadler, Walter M.. The Role of Chemotherapy in Upper Tract Urothelial Carcinoma. Advances in Urology No. 2009 (2009), pp.1-4.
https://search.emarefa.net/detail/BIM-470698
American Medical Association (AMA)
O'Donnell, Peter H.& Stadler, Walter M.. The Role of Chemotherapy in Upper Tract Urothelial Carcinoma. Advances in Urology. 2009. Vol. 2009, no. 2009, pp.1-4.
https://search.emarefa.net/detail/BIM-470698
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-470698