Resveratrol Protects the Brain of Obese Mice from Oxidative Damage
Joint Authors
Broderick, Tom L.
Mathews, Suresh T.
Kumar, Sruthi
Geetha, Thangiah
Babu, Jeganathan Ramesh
Huggins, Kevin W.
Tamura, Leslie
Wilson, David N.
Rege, Shraddha D.
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-09-15
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Natural & Life Sciences (Multidisciplinary)
Biology
Abstract EN
Resveratrol (3,5,4′-trihydroxy-trans-stilbene) is a polyphenolic phytoalexin that exerts cardioprotective, neuroprotective, and antioxidant effects.
Recently it has been shown that obesity is associated with an increase in cerebral oxidative stress levels, which may enhance neurodegeneration.
The present study evaluates the neuroprotective action of resveratrol in brain of obese (ob/ob) mice.
Resveratrol was administered orally at the dose of 25 mg kg−1 body weight daily for three weeks to lean and obese mice.
Resveratrol had no effect on body weight or blood glucose levels in obese mice.
Lipid peroxides were significantly increased in brain of obese mice.
The enzymatic antioxidants superoxide dismutase, catalase, glutathione peroxidase, glutathione reductase, glucose-6-phosphate dehydrogenase and nonenzymatic antioxidants tocopherol, ascorbic acid, and glutathione were decreased in obese mice brain.
Administration of resveratrol decreased lipid peroxide levels and upregulated the antioxidant activities in obese mice brain.
Our findings indicate a neuroprotective effect of resveratrol by preventing oxidative damage in brain tissue of obese mice.
American Psychological Association (APA)
Rege, Shraddha D.& Kumar, Sruthi& Wilson, David N.& Tamura, Leslie& Geetha, Thangiah& Mathews, Suresh T.…[et al.]. 2013. Resveratrol Protects the Brain of Obese Mice from Oxidative Damage. Oxidative Medicine and Cellular Longevity،Vol. 2013, no. 2013, pp.1-7.
https://search.emarefa.net/detail/BIM-470703
Modern Language Association (MLA)
Rege, Shraddha D.…[et al.]. Resveratrol Protects the Brain of Obese Mice from Oxidative Damage. Oxidative Medicine and Cellular Longevity No. 2013 (2013), pp.1-7.
https://search.emarefa.net/detail/BIM-470703
American Medical Association (AMA)
Rege, Shraddha D.& Kumar, Sruthi& Wilson, David N.& Tamura, Leslie& Geetha, Thangiah& Mathews, Suresh T.…[et al.]. Resveratrol Protects the Brain of Obese Mice from Oxidative Damage. Oxidative Medicine and Cellular Longevity. 2013. Vol. 2013, no. 2013, pp.1-7.
https://search.emarefa.net/detail/BIM-470703
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-470703