The Determination of Partition Coefficient of 6-Mercaptopurine Derivatives by Thin Layer Chromatography
Joint Authors
Kupczyk, Bartłomiej
Czyrski, Andrzej
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-4, 4 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-09-03
Country of Publication
Egypt
No. of Pages
4
Main Subjects
Abstract EN
Mercaptopurine and its derivatives are used in the treatment of leukemia.
To estimate their lipophilicity, a simple and novel thin layer chromatography method was developed.
The mobile phase was the mixture of acetonitrile and water.
The acetonitrile content varied by 5% from 50% to 80%.
The linear relationship between log P and Rm0 for substances with known lipophilicity was found.
The lipophilicity of purine derivatives was worked out from the calibration curve.
The most lipohilic compound was methylazathioprine (0.64).
American Psychological Association (APA)
Czyrski, Andrzej& Kupczyk, Bartłomiej. 2012. The Determination of Partition Coefficient of 6-Mercaptopurine Derivatives by Thin Layer Chromatography. Journal of Chemistry،Vol. 2013, no. 2013, pp.1-4.
https://search.emarefa.net/detail/BIM-470713
Modern Language Association (MLA)
Czyrski, Andrzej& Kupczyk, Bartłomiej. The Determination of Partition Coefficient of 6-Mercaptopurine Derivatives by Thin Layer Chromatography. Journal of Chemistry No. 2013 (2013), pp.1-4.
https://search.emarefa.net/detail/BIM-470713
American Medical Association (AMA)
Czyrski, Andrzej& Kupczyk, Bartłomiej. The Determination of Partition Coefficient of 6-Mercaptopurine Derivatives by Thin Layer Chromatography. Journal of Chemistry. 2012. Vol. 2013, no. 2013, pp.1-4.
https://search.emarefa.net/detail/BIM-470713
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-470713
