Ursolic Acid Inhibits Proliferation and Induces Apoptosis of Cancer Cells In Vitro and In Vivo
Joint Authors
Qimuge-Suyila,
Su, Xiulan
Zhang, Fan
Zhang, Jialing
Yang, Ling
Zhang, Xiaowen
Wang, Xuemei
Long, Hai
Mei, Ying
Source
Journal of Biomedicine and Biotechnology
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-05-30
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
The aims of the study are to explore the effect of ursolic acid (UA) on the growth of gastric cancer cell line BGC-803 and hepatocellular cancer cell H22 xenograft and to understand the mechanism.
UA inhibits growth of BGC-803 cells in vitro in dose-dependent and time-dependent manner.
Treated with UA in vivo, tumor cells can be arrested to G0/G1 stage.
The apoptotic rate was significantly increased in tumor cells treated with UA both in vitro and in vivo.
DNA fragmentation was found in BGC-803 cells exposed to UA.
UA activated caspase-3, -8, and -9 and down regulated expression of Bcl-2 in BGC-803 cells.
The expression of caspase-3 and -8 was elevated in tumor cells from xenograft treated with UA.
18F-FLT PET-CT imaging confirmed tumor model and UA effectiveness.
Our results indicated that UA inhibits growth of tumor cells both in vitro and in vivo by decreasing proliferation of cells and inducing apoptosis.
American Psychological Association (APA)
Wang, Xuemei& Zhang, Fan& Yang, Ling& Mei, Ying& Long, Hai& Zhang, Xiaowen…[et al.]. 2011. Ursolic Acid Inhibits Proliferation and Induces Apoptosis of Cancer Cells In Vitro and In Vivo. Journal of Biomedicine and Biotechnology،Vol. 2011, no. 2011, pp.1-8.
https://search.emarefa.net/detail/BIM-470725
Modern Language Association (MLA)
Wang, Xuemei…[et al.]. Ursolic Acid Inhibits Proliferation and Induces Apoptosis of Cancer Cells In Vitro and In Vivo. Journal of Biomedicine and Biotechnology No. 2011 (2011), pp.1-8.
https://search.emarefa.net/detail/BIM-470725
American Medical Association (AMA)
Wang, Xuemei& Zhang, Fan& Yang, Ling& Mei, Ying& Long, Hai& Zhang, Xiaowen…[et al.]. Ursolic Acid Inhibits Proliferation and Induces Apoptosis of Cancer Cells In Vitro and In Vivo. Journal of Biomedicine and Biotechnology. 2011. Vol. 2011, no. 2011, pp.1-8.
https://search.emarefa.net/detail/BIM-470725
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-470725
