![](/images/graphics-bg.png)
Preclinical Remodeling of Human Prostate Cancer through the PTENAKT Pathway
Joint Authors
Uemura, Hirotsugu
De Velasco, Marco A.
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-02-21
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
Knowledge gained from the identification of genetic and epigenetic alterations that contribute to the progression of prostate cancer in humans is now being implemented in the development of functionally relevant translational models.
GEM (genetically modified mouse) models are being developed to incorporate the same molecular defects associated with human prostate cancer.
Haploinsufficiency is common in prostate cancer and homozygous loss of PTEN is strongly correlated with advanced disease.
In this paper, we discuss the evolution of the PTEN knockout mouse and the cooperation between PTEN and other genetic alterations in tumor development and progression.
Additionally, we will outline key points that make these models key players in the development of personalized medicine, as potential tools for target and biomarker development and validation as well as models for drug discovery.
American Psychological Association (APA)
De Velasco, Marco A.& Uemura, Hirotsugu. 2012. Preclinical Remodeling of Human Prostate Cancer through the PTENAKT Pathway. Advances in Urology،Vol. 2012, no. 2012, pp.1-12.
https://search.emarefa.net/detail/BIM-470726
Modern Language Association (MLA)
De Velasco, Marco A.& Uemura, Hirotsugu. Preclinical Remodeling of Human Prostate Cancer through the PTENAKT Pathway. Advances in Urology No. 2012 (2012), pp.1-12.
https://search.emarefa.net/detail/BIM-470726
American Medical Association (AMA)
De Velasco, Marco A.& Uemura, Hirotsugu. Preclinical Remodeling of Human Prostate Cancer through the PTENAKT Pathway. Advances in Urology. 2012. Vol. 2012, no. 2012, pp.1-12.
https://search.emarefa.net/detail/BIM-470726
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-470726