Extracorporeal Immunoglobulin Elimination for the Treatment of Severe Myasthenia Gravis
Joint Authors
Lánská, M.
Maly, J.
Pit'ha, J.
Langrová, Hana
Bláha, V.
Bláha, Milan
Filip, S.
Source
Journal of Biomedicine and Biotechnology
Issue
Vol. 2010, Issue 2010 (31 Dec. 2010), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-03-15
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Myasthenia gravis (MG) is a neuromuscular disorder leading to fluctuating muscle weakness and fatigue.
Rarely, long-term stabilization is not possible through the use of thymectomy or any known drug therapy.
We present our experience with extracorporeal immunoglobulin (Ig) elimination by immunoadsorption (adsorbers with human Ig antibodies).
Acetylcholine receptor antibodies (AChRAs) were measured during long-term monitoring (4.7±2.9 years; range 1.1–8.0).
A total of 474 samples (232 pairs) were analyzed, and a drop in AChRA levels was observed (P=.025).
The clinical status of patients improved and stabilized.
Roughly 6.8% of patients experienced clinically irrelevant side effects.
The method of Ig elimination by extracorporeal immunoadsorption (IA) is a clinical application of the recent biotechnological advances.
It offers an effective and safe therapy for severe MG even when the disease is resistant to standard therapy.
American Psychological Association (APA)
Bláha, Milan& Pit'ha, J.& Bláha, V.& Lánská, M.& Maly, J.& Filip, S.…[et al.]. 2010. Extracorporeal Immunoglobulin Elimination for the Treatment of Severe Myasthenia Gravis. Journal of Biomedicine and Biotechnology،Vol. 2010, no. 2010, pp.1-6.
https://search.emarefa.net/detail/BIM-470748
Modern Language Association (MLA)
Bláha, Milan…[et al.]. Extracorporeal Immunoglobulin Elimination for the Treatment of Severe Myasthenia Gravis. Journal of Biomedicine and Biotechnology No. 2010 (2010), pp.1-6.
https://search.emarefa.net/detail/BIM-470748
American Medical Association (AMA)
Bláha, Milan& Pit'ha, J.& Bláha, V.& Lánská, M.& Maly, J.& Filip, S.…[et al.]. Extracorporeal Immunoglobulin Elimination for the Treatment of Severe Myasthenia Gravis. Journal of Biomedicine and Biotechnology. 2010. Vol. 2010, no. 2010, pp.1-6.
https://search.emarefa.net/detail/BIM-470748
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-470748