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Vitamin D Receptor Activators and Clinical Outcomes in Chronic Kidney Disease
Joint Authors
Gallieni, Maurizio
Martina, Valentina
Rizzo, Maria Antonietta
Mezzina, Nicoletta
Regalia, Anna
Gravellone, Luciana
Source
International Journal of Nephrology
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-05-15
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
Vitamin D deficiency appears to be an underestimated risk factor for cardiovascular disease in patients with chronic kidney disease.
Evidence from both basic science and clinical studies supports the possible protective role of vitamin D beyond its effect on mineral metabolism.
Toxicity of pharmacologic doses of active vitamin D metabolites, in particular calcitriol, is mainly due to the possibility of positive calcium and phosphorus balance.
Therefore, vitamin D analogs have been developed, which suppress PTH secretion and synthesis with reduced calcemic and phosphatemic effects.
Observational studies suggest that in hemodialysis patients the use of a vitamin D receptor (VDR) activator, such as calcitriol, doxercalciferol, paricalcitol, or alfacalcidol, is associated with a reduced mortality when compared with nonusers of any VDR activator.
In this article the existing literature on the topic is reviewed, although a more robust answer to the question of whether or not VDR activators have beneficial effects in hemodialysis patients will hopefully come from a randomized controlled trial.
American Psychological Association (APA)
Gravellone, Luciana& Rizzo, Maria Antonietta& Martina, Valentina& Mezzina, Nicoletta& Regalia, Anna& Gallieni, Maurizio. 2011. Vitamin D Receptor Activators and Clinical Outcomes in Chronic Kidney Disease. International Journal of Nephrology،Vol. 2011, no. 2011, pp.1-13.
https://search.emarefa.net/detail/BIM-470749
Modern Language Association (MLA)
Gravellone, Luciana…[et al.]. Vitamin D Receptor Activators and Clinical Outcomes in Chronic Kidney Disease. International Journal of Nephrology No. 2011 (2011), pp.1-13.
https://search.emarefa.net/detail/BIM-470749
American Medical Association (AMA)
Gravellone, Luciana& Rizzo, Maria Antonietta& Martina, Valentina& Mezzina, Nicoletta& Regalia, Anna& Gallieni, Maurizio. Vitamin D Receptor Activators and Clinical Outcomes in Chronic Kidney Disease. International Journal of Nephrology. 2011. Vol. 2011, no. 2011, pp.1-13.
https://search.emarefa.net/detail/BIM-470749
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-470749