A Multinomial Ordinal Probit Model with Singular Value Decomposition Method for a Multinomial Trait
Joint Authors
Taylor, Kent D.
Kwon, Soonil
Goodarzi, Mark O.
Cui, Jinrui
Hsueh, Willa A.
Guo, Xiuqing
Chen, Y.-D. Ida
Rotter, Jerome I.
Source
Journal of Probability and Statistics
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-05-29
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
We developed a multinomial ordinal probit model with singular value decomposition for testing a large number of single nucleotide polymorphisms (SNPs) simultaneously for association with multidisease status when sample size is much smaller than the number of SNPs.
The validity and performance of the method was evaluated via simulation.
We applied the method to our real study sample recruited through the Mexican-American Coronary Artery Disease study.
We found 3 genes (SORCS1, AMPD1, and PPARα) to be associated with the development of both IGT and IFG, while 5 genes (AMPD2, PRKAA2, C5, TCF7L2, and ITR) with the IGT mechanism only and 6 genes (CAPN10, IL4, NOS3, CD14, GCG, and SORT1) with the IFG mechanism only.
These data suggest that IGT and IFG may indicate different physiological mechanism to prediabetes, via different genetic determinants.
American Psychological Association (APA)
Kwon, Soonil& Goodarzi, Mark O.& Taylor, Kent D.& Cui, Jinrui& Chen, Y.-D. Ida& Rotter, Jerome I.…[et al.]. 2012. A Multinomial Ordinal Probit Model with Singular Value Decomposition Method for a Multinomial Trait. Journal of Probability and Statistics،Vol. 2012, no. 2012, pp.1-12.
https://search.emarefa.net/detail/BIM-470780
Modern Language Association (MLA)
Kwon, Soonil…[et al.]. A Multinomial Ordinal Probit Model with Singular Value Decomposition Method for a Multinomial Trait. Journal of Probability and Statistics No. 2012 (2012), pp.1-12.
https://search.emarefa.net/detail/BIM-470780
American Medical Association (AMA)
Kwon, Soonil& Goodarzi, Mark O.& Taylor, Kent D.& Cui, Jinrui& Chen, Y.-D. Ida& Rotter, Jerome I.…[et al.]. A Multinomial Ordinal Probit Model with Singular Value Decomposition Method for a Multinomial Trait. Journal of Probability and Statistics. 2012. Vol. 2012, no. 2012, pp.1-12.
https://search.emarefa.net/detail/BIM-470780
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-470780