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The Response of Hemostatic Marker Levels to Activated Factor VII in a Neonate following Cardiopulmonary Bypass
Joint Authors
Richards, Michael
Geiduschek, Jeremy M.
Joffe, Denise
Chandler, Wayne L.
Eisses, Michael J.
Source
Issue
Vol. 2009, Issue 2009 (31 Dec. 2009), pp.1-3, 3 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2009-08-31
Country of Publication
Egypt
No. of Pages
3
Main Subjects
Abstract EN
The primary function of recombinant activated factor VII (rFVIIa) is to increase thrombin formation which leads to increased fibrin and less “bleeding.” As a result, most of literature utilizes “bleeding” as the outcome measure with respect to rFVIIa.
However, we report the actual effect of rFVIIa on changes in hemostatic markers such as prothrombin activation peptide F1.2, thrombin antithrombin complex (TAT), D-dimer, tissue plasminogen activator (tPA), and plasminogen activator inhibitor (PAI) in a neonate after cardiopulmonary bypass.
A single dose of rFVIIa caused a 5.5-fold increase in F1.2, 3.5-fold increase in TAT, and a small increase in d-dimer compared to only a 1.5-fold increase, no increase, and a decrease, respectively, in two neonates undergoing the same procedure having not received rFVIIa.
The patterns of change for tPA and PAI were similar.
American Psychological Association (APA)
Eisses, Michael J.& Richards, Michael& Joffe, Denise& Geiduschek, Jeremy M.& Chandler, Wayne L.. 2009. The Response of Hemostatic Marker Levels to Activated Factor VII in a Neonate following Cardiopulmonary Bypass. Case Reports in Medicine،Vol. 2009, no. 2009, pp.1-3.
https://search.emarefa.net/detail/BIM-470792
Modern Language Association (MLA)
Eisses, Michael J.…[et al.]. The Response of Hemostatic Marker Levels to Activated Factor VII in a Neonate following Cardiopulmonary Bypass. Case Reports in Medicine No. 2009 (2009), pp.1-3.
https://search.emarefa.net/detail/BIM-470792
American Medical Association (AMA)
Eisses, Michael J.& Richards, Michael& Joffe, Denise& Geiduschek, Jeremy M.& Chandler, Wayne L.. The Response of Hemostatic Marker Levels to Activated Factor VII in a Neonate following Cardiopulmonary Bypass. Case Reports in Medicine. 2009. Vol. 2009, no. 2009, pp.1-3.
https://search.emarefa.net/detail/BIM-470792
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-470792