![](/images/graphics-bg.png)
The rs2071559 AA VEGFR-2 Genotype Frequency Is Significantly Lower in Neovascular Age-Related Macular Degeneration Patients
Joint Authors
Orlandi, Paola
Figus, Michele
Agosta, Elisa
Di Desidero, Teresa
Danesi, Romano
Cascio, Elisa
Sartini, Maria Sole
Bocci, Guido
Fioravanti, Anna
Nardi, Marco
Lazzeri, Stefano
Canu, Bastianina
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-08-01
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Natural & Life Sciences (Multidisciplinary)
Medicine
Information Technology and Computer Science
Abstract EN
In this prospective, case-control genetic study, 120 consecutive neovascular age-related macular degeneration (AMD) cases and 78 controls were enrolled.
Two SNPs (rs2071559 and rs1870377) of VEGF-A receptor-2 (VEGFR-2) gene were analyzed with the technique of Real-Time PCR to investigate a genetic link between AMD and VEGFR-2 gene polymorphisms in Italian patients.
The frequency of the VEGFR-2 genotype rs2071559 AA was significantly lower (18.33%) in patients with AMD than in the control subjects (34.62%; P=0.0095, chi-square test; Pcorr=0.038; OR=0.42, 95% CI 0.22 to 0.82).
In conclusion, although with the limitations of a small sample size and the few SNPs studied, this study demonstrates a lower frequency of VEGFR-2 rs2071559 AA genotype in an AMD patient population, suggesting future studies on the role VEGFR-2 SNPs.
American Psychological Association (APA)
Lazzeri, Stefano& Orlandi, Paola& Figus, Michele& Fioravanti, Anna& Cascio, Elisa& Di Desidero, Teresa…[et al.]. 2012. The rs2071559 AA VEGFR-2 Genotype Frequency Is Significantly Lower in Neovascular Age-Related Macular Degeneration Patients. The Scientific World Journal،Vol. 2012, no. 2012, pp.1-6.
https://search.emarefa.net/detail/BIM-470798
Modern Language Association (MLA)
Lazzeri, Stefano…[et al.]. The rs2071559 AA VEGFR-2 Genotype Frequency Is Significantly Lower in Neovascular Age-Related Macular Degeneration Patients. The Scientific World Journal No. 2012 (2012), pp.1-6.
https://search.emarefa.net/detail/BIM-470798
American Medical Association (AMA)
Lazzeri, Stefano& Orlandi, Paola& Figus, Michele& Fioravanti, Anna& Cascio, Elisa& Di Desidero, Teresa…[et al.]. The rs2071559 AA VEGFR-2 Genotype Frequency Is Significantly Lower in Neovascular Age-Related Macular Degeneration Patients. The Scientific World Journal. 2012. Vol. 2012, no. 2012, pp.1-6.
https://search.emarefa.net/detail/BIM-470798
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-470798