In Vivo Ciprofloxacin Release from Hydroxyapatite-Based Bone Implants in Rabbit Tibia : A Preliminary Study
Joint Authors
Sen, Kalyan Kumar
Bhattacharyya, Ajoy
Nayak, Amit Kumar
Source
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-4, 4 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-12-07
Country of Publication
Egypt
No. of Pages
4
Main Subjects
Abstract EN
The present study deals with the preliminary evaluation of in vivo ciprofloxacin release from HAp-ciprofloxacin bone implants in rabbit tibia.
The HAp-ciprofloxacin implants (2 × 2.5 mm) were prepared using various HAp-ciprofloxacin composites synthesized by precipitation technique and 1.5% w/v guar gum as a binder.
5 implants were implanted in artificial cortical bone window at the right proximal tibia of each rabbit.
After 3- and 6-day intervals, the rabbits were euthanized.
Bone marrow and serum concentrations of ciprofloxacin were determined from the harvested tibia using HPLC method.
The results displayed the availability of elevated local antibiotic concentration at the implanted site with the limitation of systemic antibiotic exposure, which can be useful to minimize the risk of systemic toxicity-related side effects.
This study is the preliminary investigation of the suitability of in vivo ciprofloxacin release from HAp-ciprofloxacin bone implants in rabbit tibia, after implantation, and these implants can be useful for the treatment of bacterial bone infections like osteomyelitis.
American Psychological Association (APA)
Nayak, Amit Kumar& Bhattacharyya, Ajoy& Sen, Kalyan Kumar. 2011. In Vivo Ciprofloxacin Release from Hydroxyapatite-Based Bone Implants in Rabbit Tibia : A Preliminary Study. ISRN Orthopedics،Vol. 2011, no. 2011, pp.1-4.
https://search.emarefa.net/detail/BIM-470829
Modern Language Association (MLA)
Nayak, Amit Kumar…[et al.]. In Vivo Ciprofloxacin Release from Hydroxyapatite-Based Bone Implants in Rabbit Tibia : A Preliminary Study. ISRN Orthopedics No. 2011 (2011), pp.1-4.
https://search.emarefa.net/detail/BIM-470829
American Medical Association (AMA)
Nayak, Amit Kumar& Bhattacharyya, Ajoy& Sen, Kalyan Kumar. In Vivo Ciprofloxacin Release from Hydroxyapatite-Based Bone Implants in Rabbit Tibia : A Preliminary Study. ISRN Orthopedics. 2011. Vol. 2011, no. 2011, pp.1-4.
https://search.emarefa.net/detail/BIM-470829
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-470829