![](/images/graphics-bg.png)
Effects of Supraphysiological Doses of Levothyroxine on Sleep in Healthy Subjects : A Prospective Polysomnography Study
Joint Authors
Kraemer, Susanne
Danker-Hopfe, Heidi
Pilhatsch, Maximilian
Bes, Frederik
Bauer, Michael
Source
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-07-07
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Disrupted sleep is prevalent in both mood and thyroid disorders.
Given the emerging use of thyroid hormones in the treatment of mood disorders, we investigated the effects of supraphysiological doses of levothyroxine (L-T4) on sleep.
In an open-label design, 13 healthy subjects received up to 500 μg/day for an eight-week period.
A baseline night was polysomnographically recorded (PSG) followed by PSG under the maximum tolerated dose of L-T4.
All subjects developed hyperthyroxinemia.
The heart rate and respiration rate increased significantly with treatment; a significant increase in body temperature was observed in men but not in women.
Surprisingly, treatment with supraphysiological doses of L-T4 did not cause significant effects on sleep architecture.
However, the increase in body movements and REM density was close to reaching statistical significance.
Here, we report on the sleep data, thyroid hormone levels, and physiological parameters during sleep.
We conclude that experimentally induced hyperthyroidism does not profoundly change the sleep structure in healthy individuals underlining the good tolerability of treatment with supraphysiological doses of L-T4 in patients with mood disorders.
American Psychological Association (APA)
Kraemer, Susanne& Danker-Hopfe, Heidi& Pilhatsch, Maximilian& Bes, Frederik& Bauer, Michael. 2011. Effects of Supraphysiological Doses of Levothyroxine on Sleep in Healthy Subjects : A Prospective Polysomnography Study. Journal of Thyroid Research،Vol. 2011, no. 2011, pp.1-7.
https://search.emarefa.net/detail/BIM-470832
Modern Language Association (MLA)
Kraemer, Susanne…[et al.]. Effects of Supraphysiological Doses of Levothyroxine on Sleep in Healthy Subjects : A Prospective Polysomnography Study. Journal of Thyroid Research No. 2011 (2011), pp.1-7.
https://search.emarefa.net/detail/BIM-470832
American Medical Association (AMA)
Kraemer, Susanne& Danker-Hopfe, Heidi& Pilhatsch, Maximilian& Bes, Frederik& Bauer, Michael. Effects of Supraphysiological Doses of Levothyroxine on Sleep in Healthy Subjects : A Prospective Polysomnography Study. Journal of Thyroid Research. 2011. Vol. 2011, no. 2011, pp.1-7.
https://search.emarefa.net/detail/BIM-470832
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-470832