Roles of Fatty Acid Oversupply and Impaired Oxidation in Lipid Accumulation in Tissues of Obese Rats
Joint Authors
Thalén, Pia
Kjellstedt, Ann
Ljung, Bengt
Turner, Nigel
Oakes, Nicholas D.
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-05-13
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Nutrition & Dietetics
Medicine
Abstract EN
To test the roles of lipid oversupply versus oxidation in causing tissue lipid accumulation associated with insulin resistance/obesity, we studied in vivo fatty acid (FA) metabolism in obese (Obese) and lean (Lean) Zucker rats.
Indices of local FA utilization and storage were calculated using the partially metabolizable [9,10-3H]-(R)-2-bromopalmitate (3H-R-BrP) and [U-14C]-palmitate (14C-P) FA tracers, respectively.
Whole-body FA appearance (Ra) was estimated from plasma 14C-P kinetics.
Whole-body FA oxidation rate (Rox) was assessed using 3H2O production from 3H-palmitate infusion, and tissue FA oxidative capacity was evaluated ex vivo.
In the basal fasting state Obese had markedly elevated FA levels and Ra, associated with elevated FA utilization and storage in most tissues.
Estimated rates of muscle FA oxidation were not lower in obese rats and were similarly enhanced by contraction in both lean and obese groups.
At comparable levels of FA availability, achieved by nicotinic acid, Rox was lower in Obese than Lean.
In Obese rats, FA oxidative capacity was 35% higher than that in Lean in skeletal muscle, 67% lower in brown fat and comparable in other organs.
In conclusion, lipid accumulation in non-adipose tissues of obese Zucker rats appears to result largely from systemic FA oversupply.
American Psychological Association (APA)
Oakes, Nicholas D.& Kjellstedt, Ann& Thalén, Pia& Ljung, Bengt& Turner, Nigel. 2013. Roles of Fatty Acid Oversupply and Impaired Oxidation in Lipid Accumulation in Tissues of Obese Rats. Journal of Lipids،Vol. 2013, no. 2013, pp.1-12.
https://search.emarefa.net/detail/BIM-470851
Modern Language Association (MLA)
Oakes, Nicholas D.…[et al.]. Roles of Fatty Acid Oversupply and Impaired Oxidation in Lipid Accumulation in Tissues of Obese Rats. Journal of Lipids No. 2013 (2013), pp.1-12.
https://search.emarefa.net/detail/BIM-470851
American Medical Association (AMA)
Oakes, Nicholas D.& Kjellstedt, Ann& Thalén, Pia& Ljung, Bengt& Turner, Nigel. Roles of Fatty Acid Oversupply and Impaired Oxidation in Lipid Accumulation in Tissues of Obese Rats. Journal of Lipids. 2013. Vol. 2013, no. 2013, pp.1-12.
https://search.emarefa.net/detail/BIM-470851
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-470851