Chlamydia trachomatis Immune Evasion via Downregulation of MHC Class I Surface Expression Involves Direct and Indirect Mechanisms
Joint Authors
Nagamatsu, Takeshi
Sugimoto, Jun
Quayle, Alison J.
Schust, Danny J.
Greene, Sheila J.
Ibana, Joyce A.
Source
Infectious Diseases in Obstetrics and Gynecology
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-05-29
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Genital C.
trachomatis infections typically last for many months in women.
This has been attributed to several strategies by which C.
trachomatis evades immune detection, including well-described methods by which C.
trachomatis decreases the cell surface expression of the antigen presenting molecules major histocompatibility complex (MHC) class I, MHC class II, and CD1d in infected genital epithelial cells.
We have harnessed new methods that allow for separate evaluation of infected and uninfected cells within a mixed population of chlamydia-infected endocervical epithelial cells to demonstrate that MHC class I downregulation in the presence of C.
trachomatis is mediated by direct and indirect (soluble) factors.
Such indirect mechanisms may aid in priming surrounding cells for more rapid immune evasion upon pathogen entry and help promote unfettered spread of C.
trachomatis genital infections.
American Psychological Association (APA)
Ibana, Joyce A.& Schust, Danny J.& Sugimoto, Jun& Nagamatsu, Takeshi& Greene, Sheila J.& Quayle, Alison J.. 2011. Chlamydia trachomatis Immune Evasion via Downregulation of MHC Class I Surface Expression Involves Direct and Indirect Mechanisms. Infectious Diseases in Obstetrics and Gynecology،Vol. 2011, no. 2011, pp.1-8.
https://search.emarefa.net/detail/BIM-470871
Modern Language Association (MLA)
Ibana, Joyce A.…[et al.]. Chlamydia trachomatis Immune Evasion via Downregulation of MHC Class I Surface Expression Involves Direct and Indirect Mechanisms. Infectious Diseases in Obstetrics and Gynecology No. 2011 (2011), pp.1-8.
https://search.emarefa.net/detail/BIM-470871
American Medical Association (AMA)
Ibana, Joyce A.& Schust, Danny J.& Sugimoto, Jun& Nagamatsu, Takeshi& Greene, Sheila J.& Quayle, Alison J.. Chlamydia trachomatis Immune Evasion via Downregulation of MHC Class I Surface Expression Involves Direct and Indirect Mechanisms. Infectious Diseases in Obstetrics and Gynecology. 2011. Vol. 2011, no. 2011, pp.1-8.
https://search.emarefa.net/detail/BIM-470871
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-470871