Gemcitabine Plus Carboplatin in Patients with Advanced Hepatocellular Carcinoma : Results of a Phase II Study
Joint Authors
Nasr, Khalid E.
Gobran, Nagy S.
Yassin, M.
Azmy, Aly M.
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-07-16
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
Objectives.
Assessment of gemcitabine/carboplatin combination in patients with advanced-stage hepatocellular carcinoma (HCC) in a phase II trial for safety and efficacy.
Methods.
Forty patients with previously untreated advanced-stage HCC were prospectively enrolled and subjected to gemcitabine/carboplatin regimen which consisted of gemcitabine 1000 mg/m2 on days 1 and 8, and carboplatin AUC 6 on day 1.
The treatment was repeated every 3 weeks until disease progression or limiting toxicity.
Results.
Forty patients were assessable for efficacy and toxicity.
In all, 276 treatment cycles were administered.
No toxic deaths occurred.
Hematological grade 3-4 toxicity consisted of thrombocytopenia (27% of patients) and neutropenia (24%), including 2 febrile neutropenia and anemia (9%).
Grade 3 carboplatin-induced neurotoxicity was observed in 3 (9%) patients.
ORR was 23% (95% CI, 0.10–0.29) with 9 partial responses and disease stabilization was observed in 46% (95% CI, 0.22–0.42) of patients, giving a disease control rate of 69%.
Median progression-free and overall survival times were, respectively, 5 months (95% CI: 3–8 months) and 8 months (95% CI: 6–18 months).
Conclusion.
The gemcitabine/carboplatin regimen seems to be effective, well tolerated, and active in advanced HCC.
American Psychological Association (APA)
Azmy, Aly M.& Nasr, Khalid E.& Gobran, Nagy S.& Yassin, M.. 2012. Gemcitabine Plus Carboplatin in Patients with Advanced Hepatocellular Carcinoma : Results of a Phase II Study. ISRN Oncology،Vol. 2012, no. 2012, pp.1-5.
https://search.emarefa.net/detail/BIM-470874
Modern Language Association (MLA)
Azmy, Aly M.…[et al.]. Gemcitabine Plus Carboplatin in Patients with Advanced Hepatocellular Carcinoma : Results of a Phase II Study. ISRN Oncology No. 2012 (2012), pp.1-5.
https://search.emarefa.net/detail/BIM-470874
American Medical Association (AMA)
Azmy, Aly M.& Nasr, Khalid E.& Gobran, Nagy S.& Yassin, M.. Gemcitabine Plus Carboplatin in Patients with Advanced Hepatocellular Carcinoma : Results of a Phase II Study. ISRN Oncology. 2012. Vol. 2012, no. 2012, pp.1-5.
https://search.emarefa.net/detail/BIM-470874
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-470874