Pregnancy-Associated Plasma Protein-A Levels and Coronary Angiographic Features in Acute Coronary Syndrome Patients
Author
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-02-04
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Background.
Pregnancy-associated plasma protein-A (PAPP-A) is a biomarker of plaque rupture, associated with adverse cardiac events in acute coronary syndromes (ACSs) patients.
Aim.
To identify coronary angiographic (CA) features related to PAPP-A level elevation in ACSs patients.
Methods.
Forty ACSs patients were enrolled in this prospective cohort study (level of evidence: III-prognostic).
Serum samples for PAPP-A quantitation were obtained upon coronary care unit admission.
All patients underwent CA and coronary intervention within 6 hours of sampling.
Results.
Mean age of the study cohort was 57 ± 11 years, (males: 55%, n=22).
Patients with ST-segment elevation myocardial infarction (35%, n=14) showed significantly higher serum PAPP-A level (11.8 ± 2 µg/mL), compared to non-ST-segment elevation myocardial infarction (15%, n=6) and unstable angina (50%, n=20) patients (11 ± 2.6 µg/mL and 8.7 ± 2.3 µg/mL, resp., P<0.001).
Higher PAPP-A levels were significantly associated with complex culprit lesion morphology (11.8 ± 2 µg/mL for type C lesions, 9.7± 2.5 µg/mL and 7.3 ± 3.5 µg/mL for type B and type A lesions, resp., P<0.001), while no relationship to number of diseased coronaries.
Conclusion.
Higher PAPP-A levels in ACSs patients are associated with unfavorable coronary anatomy and complex angiographic plaque features.
American Psychological Association (APA)
Shehata, Mohamed. 2014. Pregnancy-Associated Plasma Protein-A Levels and Coronary Angiographic Features in Acute Coronary Syndrome Patients. Journal of Angiology،Vol. 2014, no. 2014, pp.1-6.
https://search.emarefa.net/detail/BIM-470875
Modern Language Association (MLA)
Shehata, Mohamed. Pregnancy-Associated Plasma Protein-A Levels and Coronary Angiographic Features in Acute Coronary Syndrome Patients. Journal of Angiology No. 2014 (2014), pp.1-6.
https://search.emarefa.net/detail/BIM-470875
American Medical Association (AMA)
Shehata, Mohamed. Pregnancy-Associated Plasma Protein-A Levels and Coronary Angiographic Features in Acute Coronary Syndrome Patients. Journal of Angiology. 2014. Vol. 2014, no. 2014, pp.1-6.
https://search.emarefa.net/detail/BIM-470875
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-470875