![](/images/graphics-bg.png)
Role of Renin-Angiotensin System and Oxidative Stress on Vascular Inflammation in Insulin Resistence Model
Joint Authors
Diez, E.
Lembo, Carina
Miatello, Roberto Miguel
Renna, Nicolas Federico
Source
International Journal of Hypertension
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-01-08
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
(1) This study aims to demonstrate the causal involvement of renin angiotensin system (RAS) and oxidative stress (OS) on vascular inflammation in an experimental model of metabolic syndrome (MS) achieved by fructose administration to spontaneously hypertensive rats (FFHR) during 12 weeks.
(2) Chronic treatment with candesartan (C) (10 mg/kg per day for the last 6 weeks) or 4OH-Tempol (T) (10−3 mmol/L in drinking water for the last 6 weeks) reversed the increment in metabolic variables and systolic blood pressure.
In addition, chronic C treatment reverted cardiovascular remodeling but not T.
(3) Furthermore, chronic treatment with C was able to completely reverse the expression of NF-κB and VCAM-1, but T only reduced the expression.
C reduced the expression of proatherogenic cytokines as CINC2, CINC3, VEGF, Leptin, TNF-alpha, and MCP-1 and also significantly reduced MIP-3, beta-NGF, and INF-gamma in vascular tissue in this experimental model.
T was not able to substantially modify the expression of these cytokines.
(4) The data suggest the involvement of RAS in the expression of inflammatory proteins at different vascular levels, allowing the creation of a microenvironment suitable for the creation, perpetuation, growth, and destabilization of vascular injury.
American Psychological Association (APA)
Renna, Nicolas Federico& Lembo, Carina& Diez, E.& Miatello, Roberto Miguel. 2013. Role of Renin-Angiotensin System and Oxidative Stress on Vascular Inflammation in Insulin Resistence Model. International Journal of Hypertension،Vol. 2013, no. 2013, pp.1-9.
https://search.emarefa.net/detail/BIM-470879
Modern Language Association (MLA)
Renna, Nicolas Federico…[et al.]. Role of Renin-Angiotensin System and Oxidative Stress on Vascular Inflammation in Insulin Resistence Model. International Journal of Hypertension No. 2013 (2013), pp.1-9.
https://search.emarefa.net/detail/BIM-470879
American Medical Association (AMA)
Renna, Nicolas Federico& Lembo, Carina& Diez, E.& Miatello, Roberto Miguel. Role of Renin-Angiotensin System and Oxidative Stress on Vascular Inflammation in Insulin Resistence Model. International Journal of Hypertension. 2013. Vol. 2013, no. 2013, pp.1-9.
https://search.emarefa.net/detail/BIM-470879
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-470879