Intracellular Shuttle : The Lactate Aerobic Metabolism
Joint Authors
Caputo, Fabrizio
Cruz, Rogério Santos de Oliveira
Fernandes Mendes de Oliveira, Mariana
Turnes, Tiago
Penteado Dos Santos, Rafael
de Aguiar, Rafael Alves
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-04-19
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Natural & Life Sciences (Multidisciplinary)
Medicine
Information Technology and Computer Science
Abstract EN
Lactate is a highly dynamic metabolite that can be used as a fuel by several cells of the human body, particularly during physical exercise.
Traditionally, it has been believed that the first step of lactate oxidation occurs in cytosol; however, this idea was recently challenged.
A new hypothesis has been presented based on the fact that lactate-to-pyruvate conversion cannot occur in cytosol, because the LDH enzyme characteristics and cytosolic environment do not allow the reaction in this way.
Instead, the Intracellular Lactate Shuttle hypothesis states that lactate first enters in mitochondria and only then is metabolized.
In several tissues of the human body this idea is well accepted but is quite resistant in skeletal muscle.
In this paper, we will present not only the studies which are protagonists in this discussion, but the potential mechanism by which this oxidation occurs and also a link between lactate and mitochondrial proliferation.
This new perspective brings some implications and comes to change our understanding of the interaction between the energy systems, because the product of one serves as a substrate for the other.
American Psychological Association (APA)
Cruz, Rogério Santos de Oliveira& de Aguiar, Rafael Alves& Turnes, Tiago& Penteado Dos Santos, Rafael& Fernandes Mendes de Oliveira, Mariana& Caputo, Fabrizio. 2012. Intracellular Shuttle : The Lactate Aerobic Metabolism. The Scientific World Journal،Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-470881
Modern Language Association (MLA)
Cruz, Rogério Santos de Oliveira…[et al.]. Intracellular Shuttle : The Lactate Aerobic Metabolism. The Scientific World Journal No. 2012 (2012), pp.1-8.
https://search.emarefa.net/detail/BIM-470881
American Medical Association (AMA)
Cruz, Rogério Santos de Oliveira& de Aguiar, Rafael Alves& Turnes, Tiago& Penteado Dos Santos, Rafael& Fernandes Mendes de Oliveira, Mariana& Caputo, Fabrizio. Intracellular Shuttle : The Lactate Aerobic Metabolism. The Scientific World Journal. 2012. Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-470881
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-470881