Eosinophil-Derived Neurotoxin Is Elevated in Patients with Amyotrophic Lateral Sclerosis
Joint Authors
Chang, Sunny Li-Yun
Huang, Chien-Fu
Chang, Hao-Teng
Hwang, Chi-Shin
Hsieh, Chia-Hung
Lee, Jin-Ching
Liu, Guan-Ting
Lu, Chih-Hao
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-02-20
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Background and Objectives.
Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disease characterized by loss of motor neurons in the brainstem, motor cortex, and spinal cord.
Oxidative stress and neuroinflammation have been implicated in the pathophysiology of ALS.
Members of the family of damage-associated molecular patterns, including reactive oxygen species, high-mobility group box 1, and eosinophil-derived neurotoxin (EDN), may participate in pathological conditions.
In this study, we aim to discover new biomarker for detecting ALS.
Materials and Methods.
We examined 44 patients with ALS, 41 patients with Alzheimer’s disease, 41 patients with Parkinson’s disease, and 44 healthy controls.
The concentration of serum EDN was measured using an enzyme-linked immunosorbent assay.
Results.
EDN levels were significantly increased 2.17-fold in the serum of patients with ALS as compared with healthy controls (P<0.05).
No correlation between the levels of serum EDN and various clinical parameters of ALS was found.
Moreover, the levels of serum EDN in patients with Parkinson’s disease and Alzheimer’s disease and healthy controls were similar.
Conclusion.
A higher level of serum EDN was found specifically in patients with ALS, indicating that EDN may participate in the pathophysiology of ALS.
American Psychological Association (APA)
Liu, Guan-Ting& Hwang, Chi-Shin& Hsieh, Chia-Hung& Lu, Chih-Hao& Chang, Sunny Li-Yun& Lee, Jin-Ching…[et al.]. 2013. Eosinophil-Derived Neurotoxin Is Elevated in Patients with Amyotrophic Lateral Sclerosis. Mediators of Inflammation،Vol. 2013, no. 2013, pp.1-7.
https://search.emarefa.net/detail/BIM-470913
Modern Language Association (MLA)
Liu, Guan-Ting…[et al.]. Eosinophil-Derived Neurotoxin Is Elevated in Patients with Amyotrophic Lateral Sclerosis. Mediators of Inflammation No. 2013 (2013), pp.1-7.
https://search.emarefa.net/detail/BIM-470913
American Medical Association (AMA)
Liu, Guan-Ting& Hwang, Chi-Shin& Hsieh, Chia-Hung& Lu, Chih-Hao& Chang, Sunny Li-Yun& Lee, Jin-Ching…[et al.]. Eosinophil-Derived Neurotoxin Is Elevated in Patients with Amyotrophic Lateral Sclerosis. Mediators of Inflammation. 2013. Vol. 2013, no. 2013, pp.1-7.
https://search.emarefa.net/detail/BIM-470913
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-470913