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Promising Genetic Biomarkers of Preclinical Alzheimer's Disease : The Influence of APOE and TOMM40 on Brain Integrity
Joint Authors
Karlsson, Sari
Ferencz, Beata
Kalpouzos, Grégoria
Source
International Journal of Alzheimer's Disease
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-15, 15 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-04-09
Country of Publication
Egypt
No. of Pages
15
Main Subjects
Abstract EN
Finding biomarkers constitutes a crucial step for early detection of Alzheimer's disease (AD).
Brain imaging techniques have revealed structural alterations in the brain that may be phenotypic in preclinical AD.
The most prominent polymorphism that has been associated with AD and related neural changes is the Apolipoprotein E (APOE) ε4.
The translocase of outer mitochondrial membrane 40 (TOMM40), which is in linkage disequilibrium with APOE, has received increasing attention as a promising gene in AD.
TOMM40 also impacts brain areas vulnerable in AD, by downstream apoptotic processes that forego extracellular amyloid beta aggregation.
The present paper aims to extend on the mitochondrial influence in AD pathogenesis and we propose a TOMM40-induced disconnection of the medial temporal lobe.
Finally, we discuss the possibility of mitochondrial dysfunction being the earliest pathophysiological event in AD, which indeed is supported by recent findings.
American Psychological Association (APA)
Ferencz, Beata& Karlsson, Sari& Kalpouzos, Grégoria. 2012. Promising Genetic Biomarkers of Preclinical Alzheimer's Disease : The Influence of APOE and TOMM40 on Brain Integrity. International Journal of Alzheimer's Disease،Vol. 2012, no. 2012, pp.1-15.
https://search.emarefa.net/detail/BIM-470919
Modern Language Association (MLA)
Ferencz, Beata…[et al.]. Promising Genetic Biomarkers of Preclinical Alzheimer's Disease : The Influence of APOE and TOMM40 on Brain Integrity. International Journal of Alzheimer's Disease No. 2012 (2012), pp.1-15.
https://search.emarefa.net/detail/BIM-470919
American Medical Association (AMA)
Ferencz, Beata& Karlsson, Sari& Kalpouzos, Grégoria. Promising Genetic Biomarkers of Preclinical Alzheimer's Disease : The Influence of APOE and TOMM40 on Brain Integrity. International Journal of Alzheimer's Disease. 2012. Vol. 2012, no. 2012, pp.1-15.
https://search.emarefa.net/detail/BIM-470919
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-470919