Expression and Role of the Intermediate-Conductance Calcium-Activated Potassium Channel KCa3.1 in Glioblastoma
Joint Authors
Catacuzzeno, Luigi
Fioretti, Bernard
Franciolini, Fabio
Source
Journal of Signal Transduction
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-05-17
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Glioblastomas are characterized by altered expression of several ion channels that have important consequences in cell functions associated with their aggressiveness, such as cell survival, proliferation, and migration.
Data on the altered expression and function of the intermediate-conductance calcium-activated K (KCa3.1) channels in glioblastoma cells have only recently become available.
This paper aims to (i) illustrate the main structural, biophysical, pharmacological, and modulatory properties of the KCa3.1 channel, (ii) provide a detailed account of data on the expression of this channel in glioblastoma cells, as compared to normal brain tissue, and (iii) critically discuss its major functional roles.
Available data suggest that KCa3.1 channels (i) are highly expressed in glioblastoma cells but only scantly in the normal brain parenchima, (ii) play an important role in the control of glioblastoma cell migration.
Altogether, these data suggest KCa3.1 channels as potential candidates for a targeted therapy against this tumor.
American Psychological Association (APA)
Catacuzzeno, Luigi& Fioretti, Bernard& Franciolini, Fabio. 2012. Expression and Role of the Intermediate-Conductance Calcium-Activated Potassium Channel KCa3.1 in Glioblastoma. Journal of Signal Transduction،Vol. 2012, no. 2012, pp.1-11.
https://search.emarefa.net/detail/BIM-470932
Modern Language Association (MLA)
Catacuzzeno, Luigi…[et al.]. Expression and Role of the Intermediate-Conductance Calcium-Activated Potassium Channel KCa3.1 in Glioblastoma. Journal of Signal Transduction No. 2012 (2012), pp.1-11.
https://search.emarefa.net/detail/BIM-470932
American Medical Association (AMA)
Catacuzzeno, Luigi& Fioretti, Bernard& Franciolini, Fabio. Expression and Role of the Intermediate-Conductance Calcium-Activated Potassium Channel KCa3.1 in Glioblastoma. Journal of Signal Transduction. 2012. Vol. 2012, no. 2012, pp.1-11.
https://search.emarefa.net/detail/BIM-470932
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-470932