An Engineered Arginase FC Protein Inhibits Tumor Growth In Vitro and In Vivo
Joint Authors
Gao, Liucun
Li, Lihua
Mei, Xifan
Zhou, Yuehua
Hu, Jiehua
Sun, Meiyan
Wang, Yan
Zhang, Zhuomei
Song, Haifeng
Chen, Jun
Cheng, Bi
Gao, Xin
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-05-08
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Arginine is a semiessential amino acid required for the growth of melanoma and hepatocellular carcinoma, and the enzymatic removal of arginine by pegylated arginine deiminase (ADI) or arginase is being tested clinically.
Here, we report a genetically engineered arginase FC fusion protein exhibiting a prolonged half-life and enhanced efficacy.
The use of this enzyme to treat different tumor lines both inhibited cell proliferation and impaired cellular migration in vitro and in vivo.
Our data reinforce the hypothesis that nutritional depletion is a key strategy for cancer treatment.
American Psychological Association (APA)
Li, Lihua& Wang, Yan& Chen, Jun& Cheng, Bi& Hu, Jiehua& Zhou, Yuehua…[et al.]. 2013. An Engineered Arginase FC Protein Inhibits Tumor Growth In Vitro and In Vivo. Evidence-Based Complementary and Alternative Medicine،Vol. 2013, no. 2013, pp.1-9.
https://search.emarefa.net/detail/BIM-470982
Modern Language Association (MLA)
Li, Lihua…[et al.]. An Engineered Arginase FC Protein Inhibits Tumor Growth In Vitro and In Vivo. Evidence-Based Complementary and Alternative Medicine No. 2013 (2013), pp.1-9.
https://search.emarefa.net/detail/BIM-470982
American Medical Association (AMA)
Li, Lihua& Wang, Yan& Chen, Jun& Cheng, Bi& Hu, Jiehua& Zhou, Yuehua…[et al.]. An Engineered Arginase FC Protein Inhibits Tumor Growth In Vitro and In Vivo. Evidence-Based Complementary and Alternative Medicine. 2013. Vol. 2013, no. 2013, pp.1-9.
https://search.emarefa.net/detail/BIM-470982
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-470982