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Berberine Reduces the Metastasis of Chondrosarcoma by Modulating the αvβ3 Integrin and the PKCδ, c-Src, and AP-1 Signaling Pathways
Joint Authors
Tang, Chih-Hsin
Li, Te-Mao
Fong, Yi-Chin
Wu, Chi-Ming
Tan, Tzu-Wei
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-08-22
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Chondrosarcoma is a primary malignant bone cancer, with a potent capacity to invade locally and cause distant metastasis, especially to the lungs.
Patients diagnosed with chondrosarcoma have poor prognosis.
Berberine, an active component of the Ranunculaceae and Papaveraceae families of plant, has been proven to induce tumor apoptosis and to prevent the metastasis of cancer cells.
However, the effects of berberine in human chondrosarcoma are largely unknown.
In this study, we found that berberine did not induce cell apoptosis in human primary chondrocytes and chondrosarcoma cells.
However, at noncytotoxic concentrations, berberine reduced the migration and invasion of chondrosarcoma cancer cells.
Integrins are the major adhesive molecules in mammalian cells and have been associated with the metastasis of cancer cells.
We also found that incubation of chondrosarcoma cells with berberine reduced mRNA transcription for, and cell surface expression of, the αvβ3 integrin, with additional inhibitory effects on PKCδ, c-Src, and NF-κB activation.
Thus, berberine may be a novel antimetastasis agent for the treatment of metastatic chondrosarcoma.
American Psychological Association (APA)
Wu, Chi-Ming& Li, Te-Mao& Tan, Tzu-Wei& Fong, Yi-Chin& Tang, Chih-Hsin. 2013. Berberine Reduces the Metastasis of Chondrosarcoma by Modulating the αvβ3 Integrin and the PKCδ, c-Src, and AP-1 Signaling Pathways. Evidence-Based Complementary and Alternative Medicine،Vol. 2013, no. 2013, pp.1-10.
https://search.emarefa.net/detail/BIM-470986
Modern Language Association (MLA)
Wu, Chi-Ming…[et al.]. Berberine Reduces the Metastasis of Chondrosarcoma by Modulating the αvβ3 Integrin and the PKCδ, c-Src, and AP-1 Signaling Pathways. Evidence-Based Complementary and Alternative Medicine No. 2013 (2013), pp.1-10.
https://search.emarefa.net/detail/BIM-470986
American Medical Association (AMA)
Wu, Chi-Ming& Li, Te-Mao& Tan, Tzu-Wei& Fong, Yi-Chin& Tang, Chih-Hsin. Berberine Reduces the Metastasis of Chondrosarcoma by Modulating the αvβ3 Integrin and the PKCδ, c-Src, and AP-1 Signaling Pathways. Evidence-Based Complementary and Alternative Medicine. 2013. Vol. 2013, no. 2013, pp.1-10.
https://search.emarefa.net/detail/BIM-470986
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-470986